T7330

Teijin compound 1 hydrochloride

≥98% (HPLC), powder

• Synonym(s): N-[2-[[(3R)-1-[(4-chlorophenyl)methyl]-3-pyrrolidinyl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide hydrochloride
• Empirical Formula (Hill Notation): C₂₁H₂₁ClF₃N₃O₂·HCl
• CAS Number: 1313730-14-1
• Molecular Weight: 476.32
• MDL number: MFCD16618399
• UNSPSC Code: 51111800
• PubChem Substance ID: 329826865
• NACRES: NA.77

Properties

• assay: ≥98% (HPLC)
• form: powder
• color: white to tan
• solubility: DMSO: ≥20 mg/mL
• storage temp.: 2-8°C
• SMILES string: Cl.FC(F)(F)c1cccc(c1)C(=O)NCC(=O)N[C@@H]2CCN(C2)Cc3ccc(Cl)cc3
• InChI: 1S/C21H21ClF3N3O2.ClH/c22-17-6-4-14(5-7-17)12-28-9-8-18(13-28)27-19(29)11-26-20(30)15-2-1-3-16(10-15)21(23,24)25;/h1-7,10,18H,8-9,11-13H2,(H,26,30)(H,27,29);1H/t18-;/m1./s1
• InChI key: PGUQBBISBKGQDC-GMUIIQOCSA-N

Description

Application

Studies have reported that Trp98^2.60, Thr292^7.40, His121^3.33 and Ile263^6.55 of Teijin compound 1 significantly affect the antagonistic functions of the compound at CCR2.

Biochem/physiol Actions

Teijin compound 1 is CCR2b receptor antagonist. Teijin compound 1 inhibits cell chemotaxis induced by MCP-1. The chemokine receptors CCR2 is G protein-coupled receptors (GPCR), and is mainly expressed in monocytes, immature dendritic cells, activated T-lymphocytes and basophils.

Preparation Note

Teijin compound 1 hydrochloride is soluble in DMSO at a concentration that is greater than or equal to 20 mg/ml.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable