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T7068

Thymeleatoxin

Name: Thymeleatoxin
Brand: SIGMA

99%, solid

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About This Item

Empirical Formula (Hill Notation):

C₃₆H₃₆O₁₀

CAS Number:

94482-56-1

Molecular Weight:

628.67

MDL number:

MFCD00211206

UNSPSC Code:

12352200

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assay

99%

form

solid

color

white

solubility

DMSO: soluble
H₂O: insoluble
ethanol: soluble

storage temp.

−20°C

InChI

1S/C36H36O10/c1-19(2)34-28(42-25(38)16-15-22-11-7-5-8-12-22)21(4)35-24-17-20(3)27(39)33(24,41)31(40)32(18-37)29(43-32)26(35)30(34)44-36(45-34,46-35)23-13-9-6-10-14-23/h5-17,21,24,26,28-31,37,40-41H,1,18H2,2-4H3/b16-15+/t21-,24-,26+,28-,29+,30-,31-,32+,33-,34+,35-,36?/m1/s1

InChI key

OTTFLYUONKAFGT-WOYWLKGSSA-N

Biochem/physiol Actions

Selective activator of PKC isotypes α, β₁ and γ

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Lot/Batch Number

051K4700

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Protein kinase C isoform specificity of cholinergic potentiation of glucose-induced pulsatile 5-HT/ insulin release from mouse pancreatic islets.

Inês E Baldeiras et al.

Biological research, 39(3), 531-539 (2006-11-16)

Thymeleatoxin (TMX), an activator of Ca2+-sensitive protein kinase C (cPKC) isoforms, was used to assess the PKC isoform specificity of cholinergic potentiation of glucose (11 mM)-induced pulsatile 5-HT/insulin release (PIR) from single mouse pancreatic islets. TMX (100 nM) and carbachol

Conventional-type protein kinase C contributes to phorbol ester-induced inhibition of rat myometrial tension.

Bokyung Kim et al.

British journal of pharmacology, 139(2), 408-414 (2003-05-29)

1 Phorbol ester decreases muscle tension in the rat myometrium, and the effect is more potent in late-pregnant myometrium than in nonpregnant myometrium. In the present study, we have examined the contribution of protein kinase C (PKC) isoforms to the

PKC-dependent activation of human K(2P) 18.1 K(+) channels.

Ann-Kathrin Rahm et al.

British journal of pharmacology, 166(2), 764-773 (2011-12-16)

Two-pore-domain K(+) channels (K(2P) ) mediate K(+) background currents that modulate the membrane potential of excitable cells. K(2P) 18.1 (TWIK-related spinal cord K(+) channel) provides hyperpolarizing background currents in neurons. Recently, a dominant-negative loss-of-function mutation in K(2P) 18.1 has been

Regulation of HERG potassium channel activation by protein kinase C independent of direct phosphorylation of the channel protein.

Dierk Thomas et al.

Cardiovascular research, 59(1), 14-26 (2003-06-28)

Patients with HERG-associated long QT syndrome typically develop tachyarrhythmias during physical or emotional stress. Previous studies have revealed that activation of the beta-adrenergic system and consecutive elevation of the intracellular cAMP concentration regulate HERG channels via protein kinase A-mediated phosphorylation

c-Jun N-terminal kinase contributes to norepinephrine-induced contraction through phosphorylation of caldesmon in rat aortic smooth muscle.

Youn Ri Lee et al.

Journal of pharmacological sciences, 100(2), 119-125 (2006-02-14)

Vascular smooth muscle contraction is mediated by activation of extracellular signal-regulated kinase (ERK) 1/2, an isoform of mitogen-activated protein kinase (MAPK). However, the role of stress-activated protein kinase/c-Jun N-terminal kinase (JNK) in vascular smooth muscle contraction has not been defined.

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