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T6779

Sigma-Aldrich

Tolmetin sodium salt dihydrate

Synonym(s):

1-Methyl-5-(p-toluoyl)pyrrole-2-acetic acid sodium salt dihydrate

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About This Item

Linear Formula:
C15H14NO3Na · 2H2O
CAS Number:
Molecular Weight:
315.30
EC Number:
MDL number:
UNSPSC Code:
12161501
PubChem Substance ID:

solubility

H2O: soluble 50 mg/mL, clear, colorless

SMILES string

[Na+].[H]O[H].[H]O[H].Cc1ccc(cc1)C(=O)c2ccc(CC([O-])=O)n2C

InChI

1S/C15H15NO3.Na.2H2O/c1-10-3-5-11(6-4-10)15(19)13-8-7-12(16(13)2)9-14(17)18;;;/h3-8H,9H2,1-2H3,(H,17,18);;2*1H2/q;+1;;/p-1

InChI key

QQILXENAYPUNEA-UHFFFAOYSA-M

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Application

An NSAID. Circumvents MRP-mediated multidrug resistance. Significantly increases the cytotoxicity of the anthracyclines (doxorubicin, daunorubicin and epirubicin), as well as teniposide, VP-16 and vincristine.

pictograms

Health hazardExclamation mark

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Repr. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3


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R Scott Obach
Drug metabolism and disposition: the biological fate of chemicals, 37(8), 1581-1586 (2009-05-15)
During an investigation of the in vitro glucuronidation of benoxaprofen by human liver S-9 fraction, an unusual drug-related entity possessing a protonated molecular ion that was 74 mass units greater than the parent drug was observed. It was identified as
Mitra Jelvehgari et al.
Pharmaceutical development and technology, 15(1), 71-79 (2009-06-10)
Ethylcellulose microparticles containing tolmetin sodium, an anti-inflammatory drug, were prepared by a solvent diffusion method based on the formation of multiple W/O(1)/O(2)-emulsion. The drug used was TOL, which is water-soluble and n-hexane was used as the non-solvent. Important parameters in
David R Ely et al.
International journal of pharmaceutics, 414(1-2), 157-160 (2011-05-24)
In this work, near infrared (NIR) hyperspectral imaging was used to quantify the spatial distribution of drug in tablets containing tolmetin sodium dihydrate. Hyperspectral data cubes were generated by imaging the same spatial region of a sample while illuminated by
Cláudia Nunes et al.
The journal of physical chemistry. B, 115(43), 12615-12623 (2011-09-23)
This work focuses on the application of different biophysical techniques to study the interaction of tolmetin with membrane mimetic models of different dimensionality (liposomes, monolayers, and supported lipid bilayers) composed of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC), used as a representative phospholipid of natural
Antonio Tito et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 72(5), 1000-1006 (2009-02-03)
The formation of tolmetin/N-acetyl-l-tyrosine ethyl ester (ATEE) complex has been reported by means of both theoretical and experimental studies, including quantum mechanical calculations as well as UV-vis absorption, fluorescence and time-resolved spectroscopy measurements. It has been found that the fluorescence

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