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T5080

Sigma-Aldrich

Thymulin

lyophilized powder

Synonym(s):

Pyr-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn-OH trifluoroacetate salt, STF, Serum Thymic Factor

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About This Item

Empirical Formula (Hill Notation):
C33H54N12O15
CAS Number:
63958-90-7
Molecular Weight:
858.85
MDL number:
MFCD00076882
UNSPSC Code:
12352200
PubChem Substance ID:
329826807

biological source

synthetic (organic)

assay

97-100% (HPLC)

form

lyophilized powder

color

white

solubility

deionized water: soluble

shipped in

dry ice

storage temp.

−20°C

SMILES string

C[C@H](NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(O)=O

InChI

1S/C33H54N12O15/c1-15(39-29(55)18-6-8-24(50)40-18)27(53)42-16(4-2-3-9-34)30(56)45-21(14-47)32(58)43-17(5-7-22(35)48)28(54)38-11-25(51)37-12-26(52)41-20(13-46)31(57)44-19(33(59)60)10-23(36)49/h15-21,46-47H,2-14,34H2,1H3,(H2,35,48)(H2,36,49)(H,37,51)(H,38,54)(H,39,55)(H,40,50)(H,41,52)(H,42,53)(H,43,58)(H,44,57)(H,45,56)(H,59,60)/t15-,16-,17-,18-,19-,20-,21-/m0/s1

InChI key

LIFNDDBLJFPEAN-BPSSIEEOSA-N

Amino Acid Sequence

Glp-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn

application

Thymulin was used to study the impact of this compound on gonadotrophin-induced ovulation and on onset of puberty in mice.[1]

Biochem/physiol Actions

Thymulin also refers as serum thymic factor is a nonapeptide that reduces the hyperalgesia induced due to peripheral endotoxin administration in rats and mice.[2] It also possesses an immunomodulator function by regulating the cytokine production by peripheral blood mononuclear cells (PBMC).[3]
Thymulin, also known as Thymic Factor, is a nonapeptide produced by epithelial cell popuation in the thymus. This peptide is known for its immunomodulatory role and has neuroendocrine effects as well.

Physical form

Lyophilized from 0.1% aqueous TFA.

Other Notes

Lyophilized from 0.1% TFA in H2O

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
070M4799

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Ting-Ting Li et al.
Polymers, 11(7) (2019-07-07)
In this study, a double-walled and pomelo-like hierarchical shear thickening fluid (STF) is successfully encapsulated using the simple and environment-friendly calcium alginate encapsulation technique by instilling STF into sodium alginate (SA) and crosslinking by calcium chloride solution. The encapsulated STF
B Safieh-Garabedian et al.
International archives of allergy and immunology, 101(2), 126-131 (1993-01-01)
Thymulin is a nonapeptide hormone isolated from the thymus gland. It has immunomodulatory effects which have not yet been well defined. Its major actions have been shown to be on T-cells and their immature precursors. In this study, thymulin was
L García et al.
The Journal of endocrinology, 166(2), 381-387 (2000-08-06)
The effects of thymectomy performed on 10-day-old (Tx-10) mice on spontaneous puberty and the ovulatory response induced by gonadotrophin treatment were analysed, together with the effects of thymulin replacement from 10 days of age. Infantile thymectomy induced a delay of
Nam-Kyung Lee et al.
Scientific reports, 8(1), 766-766 (2018-01-18)
Cell signaling pathways are often shared between normal and diseased cells. How to achieve cell type-specific, potent inhibition of signaling pathways is a major challenge with implications for therapeutic development. Using the Wnt/β-catenin signaling pathway as a model system, we
Giuseppe Suaria et al.
Environment international, 136, 105494-105494 (2020-01-31)
While macroplastics have been washing up on Southern Ocean islands for decades and microplastics have been found in seabirds from the region since 1960, there are still relatively few quantitative data on the amount of plastic pollution, especially with regard
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