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T4057

Sigma-Aldrich

Tyrphostin AG 1296

≥98%

Synonym(s):

6,7-Dimethoxy-2-phenylquinoxaline

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About This Item

Empirical Formula (Hill Notation):
C16H14N2O2
CAS Number:
146535-11-7
Molecular Weight:
266.29
MDL number:
MFCD00270913
UNSPSC Code:
12352200
PubChem Substance ID:
329826783

assay

≥98%

form

powder

solubility

methylene chloride: soluble 10 mg/mL
DMSO: soluble

storage temp.

2-8°C

SMILES string

COc1cc2ncc(nc2cc1OC)-c3ccccc3

InChI

1S/C16H14N2O2/c1-19-15-8-12-13(9-16(15)20-2)18-14(10-17-12)11-6-4-3-5-7-11/h3-10H,1-2H3

InChI key

QNOXYUNHIGOWNY-UHFFFAOYSA-N

Biochem/physiol Actions

Studies have reported that phosphorylation of tyrosine 857 in PDGF β-receptor is the most susceptible to inhibition by tyrphostin AG 12962.
Selective inhibitor of platelet-derived growth factor (PDGF) receptor protein.

Preparation Note

Tyrphostin AG 1296 is soluble in methylene chloride at 10 mg/ml and is also soluble in DMSO.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Kate Chao-Wei Chen et al.
Molecular vision, 13, 374-387 (2007-03-30)
The mitogenic action of PDGF has been shown to associate with reactive oxygen species (ROS) generation, but the mechanism leading to ROS production and subsequent cell proliferation is not clear. We investigated the upstream membrane-bound target proteins involved in PDGF-stimulated
Gudrun Reiterer et al.
Cancer research, 67(16), 7765-7772 (2007-08-19)
Here, we show that the platelet-derived growth factor receptor (PDGFR) regulates myeloid and monocytic differentiation of HL-60 myeloblastic leukemia cells in response to retinoic acid (RA) and vitamin D3 (D3), respectively. Both RA and D3 decreased the expression of PDGFR-alpha
Silvia Svegliati Baroni et al.
The New England journal of medicine, 354(25), 2667-2676 (2006-06-23)
Systemic sclerosis (scleroderma) is characterized by immunologic abnormalities, injury of endothelial cells, and tissue fibrosis. Abnormal oxidative stress has been documented in scleroderma and linked to fibroblast activation. Since platelet-derived growth factor (PDGF) stimulates the production of reactive oxygen species
U Mony et al.
Leukemia, 22(7), 1395-1401 (2008-05-30)
Relapse in acute myeloid leukaemia (AML) is mediated by survival of leukaemic stem cells following remission-induction chemotherapy. It would therefore be useful to identify therapeutic agents that target leukaemic stem cells. We devised a flow cytometric chemosensitivity assay allowing 48
Pascale Piednoir et al.
Critical care medicine, 40(7), 2041-2049 (2012-06-21)
Fibroblast migration is an initiating step in fibroproliferation; its involvement during acute lung injury and acute respiratory distress syndrome remains poorly understood. The aims of this study were: 1) to determine whether bronchoalveolar lavage fluids from patients with acute lung
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