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Key Documents

SRP6542

Sigma-Aldrich

FNDC5

recombinant, expressed in E. coli, ≥95% (SDS-PAGE)

Synonym(s):

Fibronectin Type III Domain-containing Protein 5, Fibronectin Type III Repeat-containing Protein 2

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.32

recombinant

expressed in E. coli

assay

≥95% (SDS-PAGE)

form

lyophilized

mol wt

~160 kDa

packaging

pkg of 10 μg

impurities

<0.1 EU/μg endotoxin (LAL test)

UniProt accession no.

Q8NAU1

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... FNDC5(252995)

General description

Irisin is a recently described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone irisin). Irisin is cleaved from the type I membrane protein FNDC5 and improves systemic metabolism by increasing energy expenditure.
extracellular domain, human aa 32-152 / mouse aa 29-149 is untagged. FNDC5 extracellular domain has 100% identity between human, mouse and rat.

Physical form

Lyophilized in PBS.

Reconstitution

Reconstitute with 100 μsterile distilled water.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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Guo-Hua Fan et al.
Cellular signalling, 72, 109665-109665 (2020-05-01)
Therapeutic benefits and clinical application of paclitaxel for treating non-small cell lung cancers (NSCLCs) are extremely hampered due to the chemoresistance. A recent study found that fibronectin type III domain-containing protein 5 (FNDC5) was downregulated in NSCLCs cells and negatively

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