SRP6354

CD3E human

recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

• Synonym(s): T-cell surface glycoprotein CD3 epsilon chain, T3E, TCRE
• UNSPSC Code: 12352200
• NACRES: NA.32

Properties

• biological source: human
• recombinant: expressed in E. coli
• assay: ≥90% (SDS-PAGE)
• form: liquid
• mol wt: 14.1 kDa (127 aa, 23-126 aa + His Tag)
• packaging: pkg of 50 μg
• concentration: 1 mg/mL
• UniProt accession no.: P07766
• shipped in: dry ice
• storage temp.: −70°C
• Gene Information: human ... CD3E(916)

Description

General description

CD3E is the CD3-epsilonpolypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor α/β and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. Recombinant human CD3E protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Physical form

1 mg/mL in 20 mM Tris-HCl buffer (pH 8.0) containing 0.2 M NaCl, and 10% glycerol.

Safety Information

• Storage Class: 13 - Non Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable