SRP5115
P73g, GST tagged human
recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Synonym(s):
TAp73γ, TP73
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About This Item
UNSPSC Code:
12352200
NACRES:
NA.32
recombinant
expressed in baculovirus infected Sf9 cells
assay
≥70% (SDS-PAGE)
form
buffered aqueous glycerol solution
mol wt
~85 kDa
NCBI accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... TP73(7161)
General description
p73γ is a member of the p53 family of transcription factors which are involved in cellular responses to stress and development. There are four isoforms of p73 (p73α, p73β, p73δ and p73γ) which differed in their abilities to form homodimeric and heterodimeric interactions with each other and with p53. The p73 isoforms also differed in their abilities to activate transcription of the p21(Waf1) promoter and to inhibit colony formation. The p73 protein is expressed at very low levels in normal tissues and is differentially expressed in a number of tumors. p73 is a stress-response gene that activates transcription of p53-responsive genes and inhibits cell growth in a p53-like manner by inducing apoptosis.
Physical form
Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Preparation Note
after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles
Storage Class
10 - Combustible liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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V De Laurenzi et al.
The Journal of experimental medicine, 188(9), 1763-1768 (1998-11-06)
p73 has been recently identified as a new structural and functional homologue of the transcription factor p53. It is expressed in either a full-length form, alpha, or a shorter beta mRNA variant, with exon 13 spliced out. Here we report
C A Jost et al.
Nature, 389(6647), 191-194 (1997-09-20)
The protein p53 is the most frequently mutated tumour suppressor to be identified so far in human cancers. The ability of p53 to inhibit cell growth is due, at least in part, to its ability to bind to specific DNA
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