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SRP4515

Sigma-Aldrich

Artemin human

recombinant, expressed in E. coli, ≥98% (SDS-PAGE)

Synonym(s):

ART, ARTN, EVN, NBN

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About This Item

MDL number:
MFCD03099559
UNSPSC Code:
12352200
NACRES:
NA.77

biological source

human

recombinant

expressed in E. coli

assay

≥98% (SDS-PAGE)

form

lyophilized

potency

2-5 ng/mL ED50 (it′s ability to stimulate the proliferation of human SH-SY5Y cells)

mol wt

~24 kDa

packaging

pkg of 20 μg

storage condition

avoid repeated freeze/thaw cycles

impurities

endotoxin, tested

NCBI accession no.

NM_057090

UniProt accession no.

Q5T4W7

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... ARTN(9048)

General description

Human Artemin, a neurotrophic factor, belongs to the GDNF family. Artemin is a survival factor for sensory and sympathetic neurons in culture. Recombinant human Artemin is a 24.2 kDa, disulfide-linked homodimer formed by two identical 113 amino acid subunits. The gene encoding this protein is localized on human chromosome 1p34.1.

Biochem/physiol Actions

Artemin (ART/ARTN) is a survival factor for sensory and sympathetic neurons in culture. It has a role in promoting survival of neurons. ART is also involved in the differentiation and development of the central and peripheral nervous systems. The protein promotes axonal projection and migration in sympathetic neurons. Artemin restores neural damage and diminishes neuropathic pain. It has been associated with various carcinomas.

Physical form

Lyophilized from 10 mM Sodium Citrate pH 4.5 plus 150 mM NaCl.

Preparation Note

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.

Reconstitution

Reconstitute in water to a concentration of 0.1-0.5 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or –20°C for future use.
Recontitute in PBS containing at least 0.1% BSA to a concentration of 0.1-1.0 mg/mL. This stock solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or –20°C for future use.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Neurotrophic factor artemin promotes invasiveness and neurotrophic function of pancreatic adenocarcinoma in vivo and in vitro
Li Gao,et al.
Pancreas, 134 (2015)
ARTEMIN promotes de novo angiogenesis in ER negative mammary carcinoma through activation of TWIST1-VEGF-A signalling.
Banerjee A et al.
PLoS ONE, 7(11) (2012)
MouseFinder: Candidate disease genes from mouse phenotype data
Chao-Kung Chen, et al.
Human Mutation (2012)
Neurotrophic factor artemin promotes invasiveness and neurotrophic function of pancreatic adenocarcinoma in vivo and in vitro
Li Gao, Haiji Bo, et al
Pancreas, 44.1, 134-134 (2015)
ARTEMIN promotes de novo angiogenesis in ER negative mammary carcinoma through activation of TWIST1-VEGF-A signalling.
Baneerje A, et al.
PLoS ONE, 7(11) null
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