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SML3840

Sigma-Aldrich

Phenformin hydrochloride

≥98% (HPLC)

Synonym(s):

1-(Diaminomethylidene)-2-(2-phenylethyl)guanidine hydrochloride, 1-Carbamimidamido-N-(2-phenylethyl)methanimidamide hydrochloride, 1-Phenethyl-biguanide hydrochloride, N-(2-Phenylethyl)imidodicarbonimidic diamide hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C10H15N5·HCl
CAS Number:
834-28-6
Molecular Weight:
241.72
MDL number:
MFCD00035039
UNSPSC Code:
12352200
NACRES:
NA.21

Quality Level

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: 2 mg/mL, clear

storage temp.

-10 to -25°C

Biochem/physiol Actions

Phenformin is an orally available biguanide hypoglycemic drug. Phenformin can cause lactic acidosis thus it was withdrawn from most markets. Phenformin exhibits potent anticancer activity associated with AMPK activation and suppression of mTOR phosphorylation.

Caution

Hygroscopic

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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A review of phenformin, metformin, and imeglimin
Drug Development Research, 81(4), 390-401 (2020)
Rattanaporn Jaidee et al.
Naunyn-Schmiedeberg's archives of pharmacology, 393(9), 1681-1690 (2020-05-10)
Phenformin (Phen), a potent activator of AMPK, is effective against some resistant cancers. This study evaluated the inhibition of proliferation, migration, invasion, and angiogenesis by Phen in aggressive cancer cells and investigated the underlying mechanism of the inhibition. Cholangiocarcinoma (CCA)
Guanyi Liu et al.
Cells, 11(15) (2022-08-13)
The treatment of many skin inflammation diseases, such as psoriasis and atopic dermatitis, is still a challenge and inflammation plays important roles in multiple stages of skin tumor development, including initiation, promotion and metastasis. Phenformin, a biguanide drug, has been

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