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SML3769

Sigma-Aldrich

CWI1-2 Hydrochloride

≥98% (HPLC)

Synonym(s):

N,N′,N′′-Tris(5-chloro-2-hydroxybenzylideneamino)guanidine hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C22H17Cl3N6O3·HCl
CAS Number:
2408590-37-2
Molecular Weight:
556.23
UNSPSC Code:
12352200
NACRES:
NA.21
Pricing and availability is not currently available.

Quality Level

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

ClC1=CC=C(O)C(/C=N/N=C(N/N=C/C2=C(O)C=CC(Cl)=C2)N/N=C/C3=C(O)C=CC(Cl)=C3)=C1.Cl

InChI key

UXAOLDYLYMMMRC-SXOKSYETSA-N

Biochem/physiol Actions

CWI1-2 is a cell penetrant, potent and selective inhibitor of an m6A reader IGF2BP2 (Insulin-like growth factor 2 mRNA-binding protein 2). CWI1-2 potently inhibits IGF2BP2 interaction with N6-Methyladenosine (m6A) modified target transcripts. CWI1-2 exhibits potent anti-leukemia efficacy in vitro and in vivo.
Cell penetrant, potent and selective inhibitor of an m6A reader IGF2BP2

Caution

Hygroscopic

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000255000
0000255000

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Synthesis of Novel N,N?,N?-Tris[aryl(hetaryl)-methylideneamino]guanidine Derivatives as Efficient and Selective Colorimetric Sensors for Fluoride Ion
Russian Journal of Organic chemistry (2019)
The m6A reader IGF2BP2 regulates glutamine metabolism and represents a therapeutic target in acute myeloid leukemia
Cancer Cell, 40(12), 1566-1582 (2022)

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