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SML3500

Sigma-Aldrich

Colesevelam hydrochloride

≥98% (HPLC)

Synonym(s):

1-Hexanaminium, N,N,N-trimethyl-6-(2-propenylamino)-, chloride, polymer with (chloromethyl)oxirane, 2-propen-1-amine and N-2-propenyl-1-decanamine, hydrochloride, 2-Propen-1-amine, polymer with (chloromethyl)oxirane, N-2-propenyl-1-decanamine and N,N,N-trimethyl-6-(2-propenylamino)-1-hexanaminium chloride, hydrochloride, CholestaGel, Colesevelam HCl, GT 31-104

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About This Item

Linear Formula:
(C13H27N.C12H27N2.C3H7N.C3H5ClO.Cl)x.xHCl
CAS Number:
182815-44-7
UNSPSC Code:
12352200
NACRES:
NA.21

Quality Level

100

assay

≥98% (HPLC)

form

powder

mol wt

581.79 g/mol

storage condition

desiccated

color

white to beige

storage temp.

-10 to -25°C

SMILES string

C=CCNCCCCCCCCCC.C=CCNCCCCCC[N+](C)(C)C.NCC=C.ClCC1OC1.[xHCl].[Cl-]

Biochem/physiol Actions

Colesevelam hydrochloride, a polyamine polymer, is an oral, non-absorbed bile acid sequestrant. Colesevelam hydrochloride absorbs bile acids in the intestine, which increases demand for cholesterol synthesis and affectively lowers low-density lipoprotein cholesterol (LDL-C) blood levels.

Caution

Hygroscopic

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Phillipp Hartmann et al.
Hepatology international, 16(2), 359-370 (2022-01-26)
Obesity, non-alcoholic fatty liver disease (NAFLD) and its more advanced form non-alcoholic steatohepatitis (NASH) are important causes of morbidity and mortality worldwide. Bile acid dysregulation is a pivotal part in their pathogenesis. The aim of this study was to evaluate
Sanjay Kalra et al.
JPMA. The Journal of the Pakistan Medical Association, 70(5), 934-936 (2020-05-14)
Colesevelam is a bile acid sequestrant, approved for the management of both dyslipidaemia and type 2 diabetes. This review discusses the potential for the use of colesevelam in the management of type 2 diabetes. Expert opinion suggests possible indications where
Noemí Cabré et al.
Cells, 10(6) (2021-07-03)
Alcohol-related liver disease is associated with intestinal dysbiosis. Functional changes in the microbiota affect bile acid metabolism and result in elevated serum bile acids in patients with alcohol-related liver disease. The aim of this study was to identify the potential

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