SML3377
BG-3
≥98% (HPLC)
Synonym(s):
N-(4-Chlorophenyl)-6-ethyl-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine, SID 124738112
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About This Item
Empirical Formula (Hill Notation):
C14H14ClN5
CAS Number:
Molecular Weight:
287.75
UNSPSC Code:
51111800
NACRES:
NA.77
Pricing and availability is not currently available.
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Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
CC1=NC2=NC=NN2C(NC3=CC=C(Cl)C=C3)=C1CC
Biochem/physiol Actions
BG-3 is a cell penetrant, potent and selective inhibitor of Pax2 (paired-box 2) that inhibits Pax2 transactivation ability. BG-3 inhibit the ability of Pax proteins to recruit PTIP and promote H3K4 methylation at Pax binding sites. BG-3 is not cytotoxic.
cell penetrant, potent and selective inhibitor of Pax2 that inhibits Pax2 transactivation ability
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Shayna T J Bradford et al.
Cell chemical biology, 29(3), 412-422 (2021-11-26)
The Pax family of developmental control genes are frequently deregulated in human disease. In the kidney, Pax2 is expressed in developing nephrons but not in adult proximal and distal tubules, whereas polycystic kidney epithelia or renal cell carcinoma continues to
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