SML3184

Santacruzamate A

≥98% (HPLC)

• Synonym(s): CAY 10683, CAY-10683, CAY10683, N-[4-Oxo-4-[(2-phenylethyl)amino]butyl]carbamic acid ethyl ester
• Empirical Formula (Hill Notation): C₁₅H₂₂N₂O₃
• CAS Number: 1477949-42-0
• Molecular Weight: 278.35
• MDL number: MFCD28348356
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: O=C(CCCNC(OCC)=O)NCCC1=CC=CC=C1
• InChI: 1S/C15H22N2O3/c1-2-20-15(19)17-11-6-9-14(18)16-12-10-13-7-4-3-5-8-13/h3-5,7-8H,2,6,9-12H2,1H3,(H,16,18)(H,17,19)
• InChI key: HTOYBIILVCHURC-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Santacruzamate A (CAY10683) is a cell-permeable and bioavailable carbamate compound that potently inhibits HDAC2 (IC50 = 119 nM) selectively over HDAC4 and HDAC6 (IC50 = > 1 μM and 433.5 nM, respectively). CAY10683 readily enhances cellular acetylated HDAC2 levels upon LPS-stimulation and only modestly inhibits HuT-78 cutaneous T-cell lymphoma and HCT-116 colon carcinoma cells growth (GI50 = 1.4 and 29.4 uM, respectively). It alleviates acute liver failure (ALF) in rats (i.p.) and rescues cognitive deficits in APPswe/PS1dE9 mice (p.o.).

cell-permeable and bioavailable carbamate compound that potently inhibits HDAC2

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable