Skip to Content
MilliporeSigma
All Photos(1)

Key Documents

View All Documentation

SML2901

Sigma-Aldrich

MAC-545496

≥98% (HPLC)

Synonym(s):

N-(5-chloropyridin-2-ylcarbamothioyl)-3-nitro-4-(piperidin-1-yl)benzamide, N-[[(5-chloro-2-pyridinyl)amino]thioxomethyl]-3-nitro-4-(1-piperidinyl)benzamide

Sign Into View Organizational & Contract Pricing

Select a Size

5 MG
$62.79
25 MG
$269.00

$62.79

List price$66.10Save 5%
Web-Only Promotion

Available to ship onApril 08, 2025Details

Request a Bulk Order
All Photos(1)

Select a Size

Change View
5 MG
$62.79
25 MG
$269.00

About This Item

Empirical Formula (Hill Notation):
C18H18ClN5O3S
CAS Number:
838810-96-1
Molecular Weight:
419.89
MDL number:
MFCD05848166
UNSPSC Code:
12352200
NACRES:
NA.77

$62.79

List price$66.10Save 5%
Web-Only Promotion

Available to ship onApril 08, 2025Details

Request a Bulk Order

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

faint yellow to dark orange

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

S=C(Nc3ncc(cc3)Cl)NC(=O)c1cc(c(cc1)N2CCCCC2)[N+](=O)[O-]

InChI

1S/C18H18ClN5O3S/c19-13-5-7-16(20-11-13)21-18(28)22-17(25)12-4-6-14(15(10-12)24(26)27)23-8-2-1-3-9-23/h4-7,10-11H,1-3,8-9H2,(H2,20,21,22,25,28)

InChI key

AFOKREIUUQFDNW-UHFFFAOYSA-N

Biochem/physiol Actions

MAC-545496 is a potent and selective inhibitor of glycopeptide-resistance-associated protein R (GraR) that displays antivirulence and antimicrobial adjuvant properties. MAC-545496 reverses β-lactam resistance in Methicillin-resistant strains (MRSA) and synergizes with cationic antimicrobial peptides (CAMPs). It also potentiates the effects of Cefuroxime and Oxacillin MRSA strains. MAC-545496 has no effect on commensal S. epidermidis and Gram-negative bacteria such as P. aeruginosa.
potent and selective inhibitor of glycopeptide-resistance-associated protein R (GraR); antivirulent, antibacterial

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

If you need assistance, please contact Customer Support.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Omar M El-Halfawy et al.
Nature chemical biology, 16(2), 143-149 (2019-11-27)
Staphylococcus aureus is the leading cause of infections worldwide, and methicillin-resistant strains (MRSA) are emerging. New strategies are urgently needed to overcome this threat. Using a cell-based screen of ~45,000 diverse synthetic compounds, we discovered a potent bioactive, MAC-545496, that

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service