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SML2528

Sigma-Aldrich

K-TMZ

≥98% (HPLC)

Synonym(s):

8-Acetyl-3-methylimidazo[5,1-d][1,2,3,5]tetrazin-4(3H)-one

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5 MG
$81.60
25 MG
$346.00

About This Item

Empirical Formula (Hill Notation):
C7H7N5O2
CAS Number:
Molecular Weight:
193.16
UNSPSC Code:
12352200
NACRES:
NA.77

$81.60

List price$85.90Save 5%
Web-Only Promotion

Available to ship onApril 08, 2025Details


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Quality Level

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

CC(C(N=C1)=C2N1C(N(C)N=N2)=O)=O

InChI

1S/C7H7N5O2/c1-4(13)5-6-9-10-11(2)7(14)12(6)3-8-5/h3H,1-2H3

InChI key

QXYCTGXCOQXVRU-UHFFFAOYSA-N

Biochem/physiol Actions

K-TMZ is a more potent, more brain-penetrable, less toxic analog of temozolomide (TMZ). It showed superior activity to TMZ in a mouse model of glioblastoma with significantly less myelotoxicity.
Less toxic analog of temozolomide with more potent anticancer activity

pictograms

Health hazard

signalword

Warning

Hazard Classifications

Carc. 2 - Muta. 2 - Repr. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Riley L Svec et al.
ACS chemical biology, 13(11), 3206-3216 (2018-10-09)
Even in the era of personalized medicine and immunotherapy, temozolomide (TMZ), a small molecule DNA alkylating agent, remains the standard-of-care for glioblastoma (GBM). TMZ has an unusual mode-of-action, spontaneously converting to its active component via hydrolysis in vivo. While TMZ

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