SML2398
SR16832
≥98% (HPLC)
Synonym(s):
2-Chloro-N-(6-methoxyquinolin-4-yl)-5-nitrobenzamide
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About This Item
Empirical Formula (Hill Notation):
C17H12ClN3O4
CAS Number:
Molecular Weight:
357.75
UNSPSC Code:
12352200
NACRES:
NA.77
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
−20°C
SMILES string
ClC1=CC=C([N+]([O-])=O)C=C1C(NC2=C(C=C(OC)C=C3)C3=NC=C2)=O
Biochem/physiol Actions
SR16832 is a PPARγ antagonist. It acts as a dual-site covalent inhibitor of PPARγ inhibiting both orthosteric and allosteric cellular activation by the PPARγ agonists.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Richard Brust et al.
ACS chemical biology, 12(4), 969-978 (2017-02-07)
GW9662 and T0070907 are widely used commercially available irreversible antagonists of peroxisome proliferator-activated receptor gamma (PPARγ). These antagonists covalently modify Cys285 located in an orthosteric ligand-binding pocket embedded in the PPARγ ligand-binding domain and are used to block binding of
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