SML1724

Displurigen

≥98% (HPLC)

• Synonym(s): 8-Hydroxy-1,1-dioxo-2-phenylthiochromen-4-one, 8-Hydroxy-2-phenyl-4H-1-benzothiopyran-4-one-1,1-dioxide, 8-Hydroxy-2-phenyl-4H-thiochromen-4-one 1,1-dioxide
• Empirical Formula (Hill Notation): C₁₅H₁₀O₄S
• CAS Number: 96156-26-2
• Molecular Weight: 286.30
• UNSPSC Code: 12352200
• PubChem Substance ID: 329826039
• NACRES: NA.77

Properties

• assay: ≥98% (HPLC)
• form: powder
• color: white to light brown
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: −20°C
• SMILES string: O=C(C=C1C2=CC=CC=C2)C3=C(C(O)=CC=C3)S1(=O)=O

Description

Biochem/physiol Actions

Displurigen is a cell-permeable compound that disrupts the pluripotency of human embryonic stem cells by targeting HSP8/HSC70 and affects its binding to Oct4

Displurigen is a cell-permeable, phenylthiochromen-4-one derived compound that disrupts the pluripotency of human embryonic stem cells by targeting HSPA8/HSC70 and affects its binding to Oct4. Inhibits ATPase activity of HSP70 (IC50 = 225 μM). Displurigen has shown to diminish the mRNA levels of Oct4 and Nanog within 24 hours of treatment and causes a complete annihilation of OCT4+  and NANOG+  bearing cells within 4 days of treatment (~ 10 μM). It does not induce apoptosis and has no significant effect on cell cycle progression.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319
• pcodes: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable