SML1520

GS39783

≥98% (HPLC)

• Synonym(s): GS-39783, N,N′-Dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine, N4,N6-dicyclopentyl-2-(methylthio)-5-nitro-4,6-pyrimidinediamine
• Empirical Formula (Hill Notation): C₁₅H₂₃N₅O₂S
• CAS Number: 39069-52-8
• Molecular Weight: 337.44
• MDL number: MFCD06201849
• UNSPSC Code: 12352202
• PubChem Substance ID: 329825937

Properties

• assay: ≥98% (HPLC)
• form: powder
• color: faintly yellow to dark yellow
• solubility: DMSO: 5 mg/mL, clear (warmed)
• storage temp.: room temp
• SMILES string: CSc1nc(NC2CCCC2)c(c(NC3CCCC3)n1)[N+]([O-])=O
• InChI: 1S/C15H23N5O2S/c1-23-15-18-13(16-10-6-2-3-7-10)12(20(21)22)14(19-15)17-11-8-4-5-9-11/h10-11H,2-9H2,1H3,(H2,16,17,18,19)
• InChI key: GSGVDKOCBKBMGG-UHFFFAOYSA-N

Description

Biochem/physiol Actions

GS39783 is a positive allosteric modulator (PAM) of GABA-B receptors. GABAB receptor positive allosteric modulators have potential for treatment of many neuro-psychiatric disorders as well as drug dependence and seizures. The receptor is a GPCR expressed throughout the CNS; it acts as both an auto-receptor and heteroreceptor to modulate GABA release and regulate K+ channels and Ca++ channels. GS39783 has been shown to inhibit alcohol self-administration and to have an antipsychotic-like effect in animal models of addiction and schizophrenia, respectively.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302,H315,H319,H335
• pcodes: P301 + P312 + P330 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable