Skip to Content
MilliporeSigma
All Photos(1)

Key Documents

View All Documentation

SML1270

Sigma-Aldrich

YZ9

≥98% (HPLC)

Synonym(s):

3-Carbethoxy-7-hydroxycoumarin, 7-hydroxy-2-oxo-2H-1-benzopyran-3-carboxylic acid ethyl ester

Sign Into View Organizational & Contract Pricing

Select a Size

10 MG
$96.90

$96.90

Available to ship onApril 15, 2025Details

All Photos(1)

Select a Size

Change View
10 MG
$96.90

About This Item

Empirical Formula (Hill Notation):
C12H10O5
CAS Number:
6093-71-6
Molecular Weight:
234.20
UNSPSC Code:
12352200
NACRES:
NA.77

$96.90

Available to ship onApril 15, 2025Details

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

−20°C

SMILES string

[o]1c2c(cc([c]1=O)C(=O)OCC)ccc(c2)O

InChI

1S/C12H10O5/c1-2-16-11(14)9-5-7-3-4-8(13)6-10(7)17-12(9)15/h3-6,13H,2H2,1H3

InChI key

IETDBZQIWIJQJG-UHFFFAOYSA-N

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
SML0949SML0931SML2914
YZ9 ≥98% (HPLC)

SML1270

YZ9

4μ8C ≥98% (HPLC)

SML0949

4μ8C

Carbimazole ≥98% (HPLC)

SML0931

Carbimazole

EMI1 ≥98% (HPLC)

SML2914

EMI1

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 5 mg/mL, clear (warmed)

solubility

DMSO: 5 mg/mL, clear (warmed)

solubility

DMSO: 5 mg/mL, clear (warmed)

solubility

DMSO: 2 mg/mL, clear

color

white to beige

color

white to beige

color

white to beige

color

white to beige

Biochem/physiol Actions

PFKFB3 inhibitor
YZ9 is a 5, 6, 7, 8-tetrahydroxy-2-(4-hydroxyphenyl) chromen-4-one (N4A) inhibitor.[1]
YZ9 is a potent inhibitor of PFKFB3 (6-phosphfructo-2-kinase/fructose-2,6-bisphosphatase) with an IC50 = 183 nM. PFKFB3 is over expressed in many cancers and catalyzes the production of fructose-2,6-bisphosphate, which can potentiate PFK1 activity, enhancing glycolysis in tumor cells. YZ9 dose dependently inhibits proliferation of HeLa cells.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000402775
0000402775
045M4739V

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Minsuh Seo et al.
PloS one, 6(9), e24179-e24179 (2011-10-01)
Cancer cells adopt glycolysis as the major source of metabolic energy production for fast cell growth. The HIF-1-induced PFKFB3 plays a key role in this adaptation by elevating the concentration of Fru-2,6-BP, the most potent glycolysis stimulator. As this metabolic

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service