SML0683

JNJ-40418677

≥98% (HPLC)

• Synonym(s): 2-(S)-(3,5-Bis(4-(trifluoromethyl)phenyl)phenyl)-4-methylpentanoic acid
• Empirical Formula (Hill Notation): C₂₆H₂₂F₆O₂
• CAS Number: 1146594-87-7
• Molecular Weight: 480.44
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 15 mg/mL, clear
• originator: Johnson & Johnson
• relevant disease(s): Alzheimer′s disease
• storage temp.: 2-8°C

Description

Biochem/physiol Actions

JNJ-40418677 is a γ-secretase modulator that selectively blocks γ-site cleavage of the APP without affecting processing of Notch. In human neuroblastoma cells and rat primary neuronal cultures, JNJ-40418677 blocked secretion of Aβb42 (IC₅₀ = 20 nM), with no affects on total Ab concentration, Notch signaling or COX activity. In vivo experiments showed that JNJ-40418677 dose dependently inhibited Aβ42 accumulation in the brain while promoting an increase in Aβ38.

Safety Information

• pictograms: GHS06
• signalword: Danger
• hcodes: H300,H413
• pcodes: P264 - P270 - P273 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 2 Oral - Aquatic Chronic 4
• Storage Class: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable