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SML0604

Sigma-Aldrich

SB-399885 hydrochloride

≥98% (HPLC)

Synonym(s):

N-(3,5-Dichloro-2-methoxyphenyl)-4-methoxy-3-(1-piperazinyl)-benzenesulfonamide hydrochloride

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5 MG
$131.00

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5 MG
$131.00

About This Item

Empirical Formula (Hill Notation):
C18H21Cl2N3O4S · HCl
CAS Number:
402713-81-9
Molecular Weight:
482.81
UNSPSC Code:
12352200
NACRES:
NA.77

$131.00

In StockDetails

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Quality Level

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: 15 mg/mL, clear

storage temp.

room temp

SMILES string

[S](=O)(=O)(Nc3c(c(cc(c3)Cl)Cl)OC)c1cc(c(cc1)OC)N2CCNCC2

InChI

1S/C18H21Cl2N3O4S/c1-26-17-4-3-13(11-16(17)23-7-5-21-6-8-23)28(24,25)22-15-10-12(19)9-14(20)18(15)27-2/h3-4,9-11,21-22H,5-8H2,1-2H3

InChI key

ATKZKAYWARYLBW-UHFFFAOYSA-N

Biochem/physiol Actions

SB-399885 is a potent, selective, and orally active 5-HT6 receptor antagonist with greater than 200 fold selectivity over other 5-HT receptors. SB-399885 is brain penetrant and displays antidepressant and anxiolytic activity in rodent models.
SB-399885 is a potent, selective, and orally active 5-HT6 receptor antagonist; brain penetrant.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
023M4712V

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Ao Li et al.
CNS neuroscience & therapeutics, 27(8), 941-950 (2021-05-12)
General anesthesia has been widely applied in surgical or nonsurgical medical procedures, but the mechanism behind remains elusive. Because of shared neural circuits of sleep and anesthesia, whether serotonergic system, which is highly implicated in modulation of sleep and wakefulness

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