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SML0595

Sigma-Aldrich

A-286982

≥95% (HPLC)

Synonym(s):

(2E)-1-(4-Acetyl-1-piperazinyl)-3-[4-[[2-(1-methylethyl)phenyl]thio]-3-nitrophenyl]-2-propen-1-one

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About This Item

Empirical Formula (Hill Notation):
C24H27N3O4S
CAS Number:
Molecular Weight:
453.55
UNSPSC Code:
12352200
NACRES:
NA.77

assay

≥95% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 10 mg/mL, clear

storage temp.

−20°C

InChI

1S/C24H27N3O4S/c1-17(2)20-6-4-5-7-22(20)32-23-10-8-19(16-21(23)27(30)31)9-11-24(29)26-14-12-25(13-15-26)18(3)28/h4-11,16-17H,12-15H2,1-3H3/b11-9+

InChI key

HTGGAYLWTDOFDK-PKNBQFBNSA-N

Biochem/physiol Actions

A-286982 blocks binding of lymphocyte function-associated antigen-1 (LFA-1) with the cell adhesion molecule ICAM-1. The IC50 in a cell based assay is 35 nM.

Other Notes

Air sensitive

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

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