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SML0524

Sigma-Aldrich

ML277

≥98% (HPLC)

Synonym(s):

(2R)-N-[4-(4-Methoxyphenyl)-1,3-thiazol-2-yl]-1-(4-methylphenyl)sulfonylpiperidine-2-carboxamide, (R)-N-(4-(4-Methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, CID-53347902, VU0458298-2, VU0458298-3

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$129.20
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$538.00

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5 MG
$129.20
25 MG
$538.00

About This Item

Empirical Formula (Hill Notation):
C23H25N3O4S2
CAS Number:
1401242-74-7
Molecular Weight:
471.59
MDL number:
MFCD23704792
UNSPSC Code:
12352200
PubChem Substance ID:
329825530
NACRES:
NA.77

$129.20

List Price$136.00Save 5%
Web-Only Promotion

Available to ship onApril 15, 2025Details

Request a Bulk Order

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL, clear

storage temp.

2-8°C

SMILES string

COc1ccc(cc1)-c2cnc(NC(=O)[C@H]3CCCCN3S(=O)(=O)c4ccc(C)cc4)s2

InChI

1S/C23H25N3O4S2/c1-16-6-12-19(13-7-16)32(28,29)26-14-4-3-5-20(26)22(27)25-23-24-15-21(31-23)17-8-10-18(30-2)11-9-17/h6-13,15,20H,3-5,14H2,1-2H3,(H,24,25,27)/t20-/m1/s1

InChI key

UKSXJENCMIVQMU-HXUWFJFHSA-N

Application

ML277 has been used as the KCNQ1 activator to treat cells in lung metastasis assay.[1]

Biochem/physiol Actions

ML277 is a potent activator of KCNQ1 (Kv7.1) channels with >100-fold selectivity versus KCNQ2 and KCNQ4 and no activity against the hERG potassium channel up to 30 μM. KCNQ1 is a voltage-gated potassium channel required for repolarization phase of the cardiac action potential. Mutations in the KCNQ1 gene are associated with long QT syndrome (LQTS), a disorder in which the heart muscles take longer than normal to recover after each heart beat and can lead to dangerous arrhythmias such as atrial fibrillation. Activators of KCNQ1 channels could have potential use in treatments of LQTS. ML277 is the first selective and potent activator found, with an EC50 of 260 nM.
ML277 is a potent activator of KCNQ1 (Kv7.1) channels with >100-fold selectivity versus KCNQ2 and KCNQ4.

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302,H319

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000429803
0000429802
0000429802
0000429803
0000427093

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Gaelle Lentini et al.
PloS one, 12(12), e0189556-e0189556 (2017-12-16)
During the infection process, Apicomplexa discharge their secretory organelles called micronemes, rhoptries and dense granules to sustain host cell invasion, intracellular replication and to modulate host cell pathways and immune responses. Herein, we describe the Toxoplasma gondii Deg-like serine protein
Hypermethylated KCNQ1 acts as a tumor suppressor in hepatocellular carcinoma
Fan H, et al.
Biochemical and Biophysical Research Communications, 503(4), 3100-3107 (2018)
Jun Ho Lee et al.
Pflugers Archiv : European journal of physiology, 472(1), 89-102 (2020-01-11)
The group of KCNQ-encoded voltage-gated potassium (Kv7) channels includes five family members (Kv7.1-7.5). We examined the molecular expression and functional roles of Kv7 channels in corporal smooth muscle (CSM). Isolated rabbit CSM strips were mounted in an organ bath system
Xiaohong Wei et al.
PloS one, 13(3), e0192122-e0192122 (2018-03-27)
Pre-eclampsia is associated with altered maternal and placental vascular reactivity. Kv7 channels (encoded by KCNQ 1-5 genes) are a potential contributor to the regulation of vascular tone in CPAs (chorionic plate arteries) during normal pregnancy. The aim of this study
Dmitry Tsvetkov et al.
British journal of pharmacology, 174(2), 150-162 (2016-12-22)
K We used Kcnq1 R-L3 produced similar concentration-dependent relaxations (EC We conclude that K
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