Skip to Content
MilliporeSigma
All Photos(1)

Key Documents

SML0523

Sigma-Aldrich

ISPA-28

≥98% (HPLC)

Synonym(s):

N-(2,3-Dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-3-(1-ethyl-3-methyl-1H-pyrazol-4-yl)-4,5-dihydro-5-Isoxazolecarboxamide

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C21H24N6O3
CAS Number:
1006335-39-2
Molecular Weight:
408.45
UNSPSC Code:
12352200

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

H2O: 5 mg/mL, clear (warmed)

storage temp.

2-8°C

InChI

1S/C21H24N6O3/c1-5-26-12-16(13(2)23-26)17-11-18(30-24-17)20(28)22-19-14(3)25(4)27(21(19)29)15-9-7-6-8-10-15/h6-10,12,18H,5,11H2,1-4H3,(H,22,28)

InChI key

YMLINDVVJXDIRW-UHFFFAOYSA-N

Biochem/physiol Actions

ISPA-28 is an inhibitor of the plasmodial surface anion channel (PSAC).
ISPA-28 is an inhibitor of the plasmodial surface anion channel (PSAC). ISPA-28 is 800 fold more potent against PSAC expressed by the P. falciparum strain Dd2 over PSAC expressed by the HB23 strain. PSAC is incorporated into the membranes of Plasmodium-infected red blood cells, resulting in increased permeability to nutrients required for pathogen growth.

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
093M4711V

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Paresh Sharma et al.
The Journal of biological chemistry, 288(27), 19429-19440 (2013-05-31)
Acquired antimalarial drug resistance produces treatment failures and has led to periods of global disease resurgence. In Plasmodium falciparum, resistance is known to arise through genome-level changes such as mutations and gene duplications. We now report an epigenetic resistance mechanism
David A Hill et al.
Future microbiology, 5(1), 81-97 (2009-12-22)
Erythrocytes infected with plasmodia, including those that cause human malaria, have increased permeability to a diverse collection of organic and inorganic solutes. While these increases have been known for decades, their mechanistic basis was unclear until electrophysiological studies revealed flux

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service