SML0442

ML239

≥98% (HPLC)

• Synonym(s): (2,4,6-Trichloro-phenoxy)-acetic acid (1H-pyrrol-2-ylmethylene)-hydrazide
• Empirical Formula (Hill Notation): C₁₃H₁₀Cl₃N₃O₂
• CAS Number: 1378872-36-6
• Molecular Weight: 346.60
• MDL number: MFCD23098913
• UNSPSC Code: 12352200
• PubChem Substance ID: 329824724
• NACRES: NA.77

Properties

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 15 mg/mL (clear solution)
• storage temp.: 2-8°C
• SMILES string: Clc1cc(Cl)c(OCC(=O)N\N=C\c2ccc[nH]2)c(Cl)c1
• InChI: 1S/C13H10Cl3N3O2/c14-8-4-10(15)13(11(16)5-8)21-7-12(20)19-18-6-9-2-1-3-17-9/h1-6,17H,7H2,(H,19,20)/b18-6+
• InChI key: NVEDPFICKAIHKD-NGYBGAFCSA-N

Description

Application

ML239 has been used as a proble in cellular lipid profiling.

Biochem/physiol Actions

ML239 decreases the saturated and monounsaturated lysophosphatidylethanolamines in lung cancer cells and is toxic to breast cancer cells. ML239 may elicit toxicity by modulating the nuclear factor−κB (NF-κB) associated pathways.

ML239 is an inhibitor of breast cancer stem cells found from a screen using stem cell-like human mammary epithelial cells (HMLE). ML239 inhibited cancer stem cells with an IC₅₀ of 1.16 μM with 24-fold selectivity against the control cell line.

Safety Information

• pictograms: GHS07,GHS09
• signalword: Warning
• hcodes: H302 + H312 + H332,H315,H319,H335,H400
• pcodes: P273 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Acute 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable