SML0373

CZC-25146 hydrochloride

≥98% (HPLC)

• Synonym(s): N-[2-[[5-Fluoro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-methanesulfonamide hydrochloride
• Empirical Formula (Hill Notation): C₂₂H₂₅FN₆O₄S · HCl
• CAS Number: 1435934-18-1
• Molecular Weight: 525.00
• MDL number: MFCD22417347
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825374
• NACRES: NA.77

Properties

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: >15 mg/mL (warmed)
• storage temp.: 2-8°C
• SMILES string: Cl.COc1cc(ccc1Nc2ncc(F)c(Nc3ccccc3NS(C)(=O)=O)n2)N4CCOCC4
• InChI: 1S/C22H25FN6O4S.ClH/c1-32-20-13-15(29-9-11-33-12-10-29)7-8-19(20)26-22-24-14-16(23)21(27-22)25-17-5-3-4-6-18(17)28-34(2,30)31;/h3-8,13-14,28H,9-12H2,1-2H3,(H2,24,25,26,27);1H
• InChI key: SKYQTYQDKAOHLP-UHFFFAOYSA-N

Description

Biochem/physiol Actions

CZC-25146 is a potent selective LRRK2 inhibitor.

CZC-25146 is a potent selective and metabolically stable inhibitor of leucine-rich repeat kinase-2 (LRRK2) also known as dardarin or PARK8, a kinase with mutations linked to Parkinson′s disease. Because the most common mutation, G2019S, enhances LRRK2 kinase activity, it is hoped that LRRK2 inhibitors may be useful in treating the disease. CZC-25146 was shown to prevent mutant LRRK2-induced injury of cultured rodent and human neurons with mid-nanomolar potency.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable