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SML0314

Sigma-Aldrich

CGP77675

≥98% (HPLC)

Synonym(s):

1-(2-{4-[4-Amino-5-(3-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]phenyl}ethyl)piperidin-4-ol, 1-(4-(4-Amino-5-(3-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenethyl)piperidin-4-ol, CGP 77675, CGP-77675

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5 MG
$153.90
25 MG
$584.10

About This Item

Empirical Formula (Hill Notation):
C26H29N5O2
CAS Number:
234772-64-6
Molecular Weight:
443.54
MDL number:
MFCD20039929
UNSPSC Code:
12352200
PubChem Substance ID:
329825319
NACRES:
NA.77

$153.90

List Price$162.00
Web-Only Promotion

Available to ship onApril 18, 2025Details

Request a Bulk Order

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: >10 mg/mL

storage temp.

2-8°C

SMILES string

COc1cccc(c1)-c2cn(-c3ccc(CCN4CCC(O)CC4)cc3)c5ncnc(N)c25

InChI

1S/C26H29N5O2/c1-33-22-4-2-3-19(15-22)23-16-31(26-24(23)25(27)28-17-29-26)20-7-5-18(6-8-20)9-12-30-13-10-21(32)11-14-30/h2-8,15-17,21,32H,9-14H2,1H3,(H2,27,28,29)

InChI key

WUPXZZWTHIZICK-UHFFFAOYSA-N

General description

CGP77675 belongs to the pyrrolopyrimidine class of inhibitors.[1]

Application

CGP77675 has been used in the generation of mouse expanded potential stem cells.[2]

Biochem/physiol Actions

CGP77675 is a potent Src kinase inhibitor.
CGP77675 is a potent Src kinase inhibitor. CGP77675 is selective toward other protein kinases including Cdc2 (>500-fold), epidermal growth factor (EGF) receptor (7.5-fold), vascular endothelial growth factor receptor (>50-fold), and for v-Abl (15-fold) and focal adhesion kinase (Fak) (>25-fold).
CGP77675 prevents hypercalcemia stimulated by interleukin 1β. It is known to offer protection against bone loss in ovariectomized mice.[1] CGP77675 is known for its use in cancer treatment.[3]

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000220773
0000222687
0000222686
042M4602V

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Osteoporosis, 798-798 (2001)
Targeted Interference with Signal Transduction Events, 177-177 (2007)
Ingun Heiene Tveteraas et al.
Journal of experimental & clinical cancer research : CR, 31, 72-72 (2012-09-13)
It is important to understand the mechanisms by which the cells integrate signals from different receptors. Several lines of evidence implicate epidermal growth factor (EGF) receptor (EGFR) in the pathophysiology of hepatocarcinomas. Data also suggest a role of prostaglandins in
Establishment of mouse expanded potential stem cells
Yang J, et al.
Nature, 550(7676), 393-393 (2017)
Wataru Hirata et al.
Experimental animals (2021-09-22)
In mammals, sexual fate is determined by the chromosomes of the male and female gametes during fertilization. Males (XY) or females (XX) are produced when a sperm containing a Y or X-chromosome respectively fertilizes an X-chromosome-containing unfertilized egg. However, sexing
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Src is the original member of a group of non-receptor protein-tyrosine kinases termed the Src family kinases (SFKs). Learn about the SFKs that, in humans, consist of eight members, a small group of atypical members, and two related kinases.

Discover Bioactive Small Molecules for Kinase Phosphatase Biology

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