Skip to Content
MilliporeSigma
All Photos(1)

Documents

SML0151

Sigma-Aldrich

CCT036477

≥98% (HPLC)

Synonym(s):

α-(4-Chlorophenyl)-2-methyl-N-2-pyridinyl-1H-indole-3-methanamine

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C21H18ClN3
CAS Number:
305372-78-5
Molecular Weight:
347.84
MDL number:
MFCD01831143
UNSPSC Code:
12352200
PubChem Substance ID:
329825199
NACRES:
NA.77

assay

≥98% (HPLC)

form

powder

color

white to tan

solubility

DMSO: ≥20 mg/mL (warm to 60°C)

storage temp.

−20°C

SMILES string

Cc1[nH]c2ccccc2c1C(Nc3ccccn3)c4ccc(Cl)cc4

InChI

1S/C21H18ClN3/c1-14-20(17-6-2-3-7-18(17)24-14)21(15-9-11-16(22)12-10-15)25-19-8-4-5-13-23-19/h2-13,21,24H,1H3,(H,23,25)

InChI key

IFOHRIXRQPOHQZ-UHFFFAOYSA-N

Biochem/physiol Actions

CCT036477 is an inhibitor of Wnt signaling. It does not alter β-catenin levels but blocks transcription at the β-catenin level. CCT036477 inhibited growth in several cancer cell lines and showed clear activity in vivo, blocking development of Zebrafish and Xenopus embryos and expression of Wnt target genes.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Linwei Li et al.
PLoS genetics, 15(2), e1007996-e1007996 (2019-02-15)
Pharyngeal pouches, a series of outpocketings that bud from the foregut endoderm, are essential to the formation of craniofacial skeleton as well as several important structures like parathyroid and thymus. However, whether pharyngeal pouch progenitors exist in the developing gut
Rohit Mathur et al.
Journal of hematology & oncology, 8, 63-63 (2015-06-07)
Mantle cell lymphoma (MCL) is an aggressive and incurable form of non-Hodgkin's lymphoma. Despite initial intense chemotherapy, up to 50% of cases of MCL relapse often in a chemoresistant form. We hypothesized that the recently identified MCL-initiating cells (MCL-ICs) are

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service