SML0135

GPV574

≥98% (HPLC)

• Synonym(s): 1-[4-[3-[4-(2,3-dimethylphenyl)-1-piperazinyl]-2-hydroxypropoxy]phenyl]-ethanone
• Empirical Formula (Hill Notation): C₂₃H₃₀N₂O₃
• CAS Number: 635703-12-7
• Molecular Weight: 382.50
• MDL number: MFCD20527325
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825184
• NACRES: NA.25

Properties

• assay: ≥98% (HPLC)
• form: powder
• color: white to tan
• solubility: DMSO: ≥10 mg/mL (warmed to 60°C)
• storage temp.: 2-8°C
• SMILES string: CC(=O)c1ccc(OCC(O)CN2CCN(CC2)c3cccc(C)c3C)cc1
• InChI: 1S/C23H30N2O3/c1-17-5-4-6-23(18(17)2)25-13-11-24(12-14-25)15-21(27)16-28-22-9-7-20(8-10-22)19(3)26/h4-10,21,27H,11-16H2,1-3H3
• InChI key: KQZDGQRWGREOJP-UHFFFAOYSA-N

Description

Biochem/physiol Actions

GPV574 is a derivative of the Class 1C antiarrhythmic drug propafenone. GPV574 inhibits the delayed rectifier K+ channel HERG with similar affinity and time constant as propafenone (IC50 = 5 mM), but unlike the parent compound, does not remain permanently trapped in the channel pore. After wash-out of GPV574, channel activity is recovered within 60 seconds.

Safety Information

• pictograms: GHS09
• signalword: Warning
• hcodes: H400
• pcodes: P273
• Hazard Classifications: Aquatic Acute 1
• Storage Class: 13 - Non Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable