SMB01078

Inulicin

≥90% (LC/MS-ELSD)

• Synonym(s): 1-O-Acetylbritannilactone, Britannilactone 1-O-acetate
• Empirical Formula (Hill Notation): C₁₇H₂₄O₅
• CAS Number: 33627-41-7
• Molecular Weight: 308.37
• MDL number: MFCD30207877
• UNSPSC Code: 12352205
• NACRES: NA.25

Properties

• biological source: plant
• assay: ≥90% (LC/MS-ELSD)
• form: solid
• mol wt: 308.37
• application(s): metabolomics; vitamins, nutraceuticals, and natural products
• storage temp.: −20°C
• InChI: 1S/C17H24O5/c1-9(6-5-7-21-12(4)18)14-10(2)8-13-15(16(14)19)11(3)17(20)22-13/h9,13,15-16,19H,3,5-8H2,1-2,4H3/t9-,13+,15+,16+/m0/s1
• InChI key: QKUFZFLZBUSEHN-CZLJMHDISA-N

Description

General description

Inulicin, a sesquiterpene lactone, is a natural bioactive compound commonly sourced from plants like Pentanema britannicum and Inula japonica. Current research indicates that this plant-derived metabolite may possess inhibitory properties, showcasing a range of biological activities, including anti-inflammatory, cardioprotective, antiangiogenic, and anticancer activities.

Application

Inulicin is a natural product derived from plant source that finds application in compound screening libraries, metabolomics, phytochemical, and pharmaceutical research.

Biochem/physiol Actions

Inulicin exhibits anticancer properties by inhibiting angiogenesis and lung cancer cell proliferation, potentially through the regulation of VEGFR-Src-FAK signaling. When combined with gemcitabine, it promotes strong apoptosis in lung cancer cells. Additionally, Inulicin shows promise in the treatment of various cardiovascular diseases, including chronic ischemia, by modulating VEGF signaling and angiogenesis. It also serves as a potent inhibitor of LPS-induced inflammatory responses in vascular smooth muscle cells, acting through the blockade of NF-kappaB activity and the suppression of the inflammatory gene COX-2. Furthermore, Inulicin displays potential as a natural skin-lightening agent, reducing melanogenesis by suppressing tyrosinase expression via ERK and Akt signaling pathways.

Features and Benefits

• Suitable for Biochemical and Biomedical research
• Versatile and adaptable for wide variety of laboratory and research applications

Other Notes

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Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable