SBR00074

Asunaprevir

≥99% (HPLC), powder

• Synonym(s): SM-5887, BMS650032, 3-Methyl-N-{[(2-methyl-2-propanyl)oxy]carbonyl}-L-valyl-(4R)-4-[(7-chloro-4-methoxy-1-isoquinolinyl)oxy]-N-{(1R,2S)-1-[(cyclopropylsulfonyl)carbamoyl]-2-vinylcyclopropyl}-L-prolinamide, ASV, BMS 650032, BMS-650032
• Empirical Formula (Hill Notation): C₃₅H₄₆ClN₅O₉S
• CAS Number: 630420-16-5
• Molecular Weight: 748.29
• MDL number: MFCD27987900
• UNSPSC Code: 51101500

Properties

• Quality Level: 100
• assay: ≥99% (HPLC)
• form: powder
• color: white to off-white
• antibiotic activity spectrum: viruses
• mode of action: protein synthesis | inhibits
• storage temp.: −20°C (−15°C to −25°C)
• SMILES string: CC(C)(C)[C@@H](C(=O)N1C[C@@H](C[C@H]1C(=O)N[C@@]2(C[C@H]2C=C)C(=O)NS(=O)(=O)C3CC3)OC4=NC=C(C5=C4C=C(C=C5)Cl)OC)NC(=O)OC(C)(C)C
• InChI: 1S/C35H46ClN5O9S/c1-9-19-16-35(19,31(44)40-51(46,47)22-11-12-22)39-28(42)25-15-21(49-29-24-14-20(36)10-13-23(24)26(48-8)17-37-29)18-41(25)30(43)27(33(2,3)4)38-32(45)50-34(5,6)7/h9-10,13-14,17,19,21-22,25,27H,1,11-12,15-16,18H2,2-8H3,(H,38,45)(H
• InChI key: XRWSZZJLZRKHHD-QGQNBIQGSA-N

Description

General description

Asunaprevir is a competitive inhibitor of HCV NS3/4A protease which act by inhibiting the protease activity of the NS3/4A enzyme of the hepatitis C virus.

Biochem/physiol Actions

Asunaprevir is a direct acting antiviral agent that inhibits the NS3/4A protease of the hepatitis C virus (HCV). Inhibition of the NS3/4A protease prevents viral replication and leads to the clearance of HCV from the body. Asunaprevir is active again viruses.

Safety Information

• pictograms: GHS08
• signalword: Warning
• hcodes: H373
• pcodes: P260 - P314 - P501
• Hazard Classifications: STOT RE 2
• target_organs: Liver
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable