SBR00066

Amikacin Ready Made Solution

25 mg/mL in water

• CAS Number: 149022-22-0
• UNSPSC Code: 51281632
• NACRES: NA.76

Properties

• form: liquid
• Quality Level: 200
• specific activity: Antibacterial
• concentration: 25 mg/mL in water
• antibiotic activity spectrum: Gram-negative bacteria; Gram-positive bacteria; mycobacteria
• mode of action: protein synthesis | interferes
• storage temp.: 2-8°C
• SMILES string: O=C([C@@H](O)CCN)N[C@H]1[C@H](O[C@@H]2[C@H](O)[C@@H](N)[C@H](O)[C@@H](CO)O2)[C@@H](O)[C@H](O[C@@H]3[C@H](O)[C@@H](O)[C@H](O)[C@@H](CN)O3)[C@@H](N)C1.O=S(O)(O)=O.[F,Cl,Br,I]
• InChI: 1S/C22H43N5O13.H2O4S/c23-2-1-8(29)20(36)27-7-3-6(25)18(39-22-16(34)15(33)13(31)9(4-24)37-22)17(35)19(7)40-21-14(32)11(26)12(30)10(5-28)38-21;1-5(2,3)4/h6-19,21-22,28-35H,1-5,23-26H2,(H,27,36);(H2,1,2,3,4)/t6-,7+,8-,9+,10+,11-,12+,13+,14+,15-,16+,17-,18+,19-,21+,22+;/m0./s1
• InChI key: HIBICIOPDUTNRR-XTHCGPPUSA-N

Description

General description

Amikacin is semisynthetic aminoglycoside antibiotic derived from kanamycin A.[1] Amikacin has broad spectrum activity against serious gram-negative bacilli drug resistant infections and also mycobacteria type infections.[2] Amikacin binds to 30S bacterial ribosomal subunit causing a change of conformation, thus disrupting mRNA’s interaction with tRNA and hampering bacterial growth.[3] Amikacin also showed potency against some gram-positive bacteria like methicillin-resistant Staphylococcus aureus (MRSA).[4] Amikacin is extensively used for multidrug resistant tuberculosis treatment[5] with 1ug/mL MIC value against Mycobacterium tuberculosis. Additionally, Amikacin MIC studies of gram negative and gram positive bacteria showed MIC distribution range of 0.094-48µg/ml.[6] Several other studies showed that Amikacin has a synergistic effect combined with β-lactams against methicillin-resistant Staphylococcus spp. strains[7] and Pseudomonas aeruginosa.[8] Amikacin is additionally used for wound healing assays at concentration of 250 µg/mL.

Other Notes

The suggested concentration of Amikacin for assays is 0.094-250 µg/mL[9][10] therefore, it is recommended to dilute the ready made solution 1:100-266,000. Amikacin:Sulfate ratio 1:1.8

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H317
• pcodes: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Hazard Classifications: Skin Sens. 1
• Storage Class: 12 - Non Combustible Liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable