SAB5700422

Anti-Phospho-TNK2-Y284 antibody produced in rabbit

• Synonym(s): ACK, ACK-1, ACK1, TNK2, p21cdc42Hs
• UNSPSC Code: 12352203
• NACRES: NA.43

Properties

• biological source: rabbit
• Quality Level: 100
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: 114; 119; 60
• species reactivity: human
• concentration: 1.71 mg/ml
• technique(s): western blot: 1:500-1:2000
• UniProt accession no.: Q07912
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: phosphorylation (pTyr284)
• Gene Information: human ... TNK2(10188)

Description

General description

This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined.

Immunogen

A synthetic phosphorylated peptide around Y284 of human TNK2 (NP_005772.3).

Physical form

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Storage and Stability

Store at -20℃. Avoid freeze / thaw cycles.

Safety Information

• Storage Class: 12 - Non Combustible Liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable