SAB5700324

Anti-Phospho-Rb-S811 antibody produced in rabbit

• Synonym(s): OSRC, PPP1R130, RB, RB1, Rb, p105-Rb, pRb, pp110
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: 106
• species reactivity: human
• concentration: 0.55 mg/ml
• technique(s): immunofluorescence: 1:50-1:100; western blot: 1:1000-1:2000
• UniProt accession no.: P06400
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: phosphorylation (pSer811)
• Gene Information: human ... RB1(5925)

Description

General description

The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.

Immunogen

A synthetic phosphorylated peptide around S811 of human Rb (NP_000312.2).

Physical form

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Storage and Stability

Store at -20℃. Avoid freeze / thaw cycles.

Safety Information

• Storage Class: 12 - Non Combustible Liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable