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SAB5200888

Sigma-Aldrich

Monoclonal Anti-Glun2A/Nr2A antibody produced in mouse

clone S327-95, purified immunoglobulin

Synonym(s):

Anti-GRIN2A, Anti-HNR2A, Anti-NMDA 2A

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

S327-95, monoclonal

form

buffered aqueous solution

mol wt

antigen predicted mol wt 170 kDa

species reactivity

mouse, human, rat

concentration

1 mg/mL

technique(s)

immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable

isotype

IgG2a

NCBI accession no.

NP_036705.3

UniProt accession no.

Q12879

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

rat ... Grin2a(24409)

Immunogen

Fusion protein amino acids 75-325 (extracellular N-terminus) of rat GluN2A/NR2A

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

PBS pH7.4, 50% glycerol, 0.09% sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Rebecca Krall et al.
Neuroscience letters, 790, 136896-136896 (2022-10-07)
Zinc, loaded into glutamate-containing presynaptic vesicles and released into the synapse in an activity-dependent manner, modulates neurotransmission through its actions on postsynaptic targets, prominently via high-affinity inhibition of GluN2A-containing NMDA receptors. Recently, we identified a postsynaptic transport mechanism that regulates
Annabel Romero-Hernandez et al.
Neuron, 92(6), 1324-1336 (2016-12-06)
Zinc is vastly present in the mammalian brain and controls functions of various cell surface receptors to regulate neurotransmission. A distinctive characteristic of N-methyl-D-aspartate (NMDA) receptors containing a GluN2A subunit is that their ion channel activity is allosterically inhibited by
Jeremiah D Paskus et al.
Cell reports, 29(10), 2944-2952 (2019-12-05)
The RhoGEFs Kalirin-7 and Trio are regulators of synaptic plasticity, and their dysregulation is associated with a range of neurodevelopmental and neurodegenerative disorders. Although studies have implicated both Kalirin and Trio in certain diseases, such as tauopathies, they remarkably differ

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