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SAB4503712

Sigma-Aldrich

Anti-GAB2 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

GRB2-associated binder 2, GRB2-associated-binding protein 2, Growth factor receptor bound protein 2-associated protein 2, KIAA0571, pp100

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About This Item

MDL number:
MFCD02686157
UNSPSC Code:
12352203

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 74 kDa

species reactivity

rat, human, mouse

concentration

~1 mg/mL

technique(s)

ELISA: 1:40000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI accession no.

Q9UQC2

UniProt accession no.

Q9UQC2

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... GAB2(9846)

General description

Anti-GAB2 Antibody detects endogenous levels of total GAB2 protein.
GAB2 (GRB2 associated binding protein 2), a mammalian homolog of GAB1 is a member of the family of insulin receptor substrate 1-like multi-substrate proteins. It is located on human chromosome 11q14.

Immunogen

The antiserum was produced against synthesized peptide derived from human Gab2.

Immunogen Range: 125-174

Biochem/physiol Actions

GAB2 (GRB2 associated binding protein 2) plays a major role in proliferation, survival and differentiation. It induces the multiplication of cells by initiating the extracellular signal-regulated kinase (ERK) signaling pathway in hepatocellular carcinoma.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Cleavage of Grb2-Associated Binding Protein 2 by Viral Proteinase 2A during Coxsackievirus Infection
Deng H, et al.
Frontiers in Cellular and Infection Microbiology (2017)
GAB2 promotes cell proliferation by activating the ERK signaling pathway in hepatocellular carcinoma
Chen Y, et al.
Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine, 37(9), 11763-11773 (2016)
Eric M Reiman et al.
Neuron, 54(5), 713-720 (2007-06-08)
The apolipoprotein E (APOE) epsilon4 allele is the best established genetic risk factor for late-onset Alzheimer's disease (LOAD). We conducted genome-wide surveys of 502,627 single-nucleotide polymorphisms (SNPs) to characterize and confirm other LOAD susceptibility genes. In epsilon4 carriers from neuropathologically

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