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SAB4502829

Sigma-Aldrich

Anti-Synuclein-α antibody produced in rabbit

affinity isolated antibody

Synonym(s):

α-synuclein, NACP, Non-A β component of AD amyloid, Non-A4 component of amyloid precursor, SNCA

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About This Item

MDL number:
MFCD02095740
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 14 kDa

species reactivity

mouse, rat, human

concentration

~1 mg/mL

technique(s)

ELISA: 1:40000
western blot: 1:500-1:1000

NCBI accession no.

P37840

UniProt accession no.

P37840

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... SNCA(6622)

General description

Anti-Synuclein-α antibody detects endogenous levels of total Synuclein-α protein.
The SNCA (synuclein α) gene is mapped to human chromosome 4q22.1.

Immunogen

The antiserum was produced against synthesized peptide derived from human Synuclein-alpha.

Immunogen Range: 86-135

Biochem/physiol Actions

Accumulation of α-synuclein in oligodendrocytes results in the loss of myelin and causes neurodegeneration, leading to multiple system atrophy. Synuclein-α is known to induce oligodendrocyte maturation. The encoded protein is considered to be an important aggregate of Lewy bodies, contributing to the pathogenesis of Parkinson disease.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Jian-Feng Li et al.
Foods (Basel, Switzerland), 13(9) (2024-05-11)
Parkinson's disease (PD), the second most common neurodegenerative disorder, is linked to α-synuclein (α-Syn) aggregation. Despite no specific drug being available for its treatment, curcumin, from the spice turmeric, shows promise. However, its application in PD is limited by a
Synucleins Have Multiple Effects on Presynaptic Architecture.
Vargas KJ
Cell Reports, 18(1), 161-173 (2017)
SNCA variants are associated with increased risk for multiple system atrophy.
Scholz SW
Annals of Neurology, 65(5), 610-614 (2009)
?-Synuclein-induced myelination deficit defines a novel interventional target for multiple system atrophy.
Ettle B
Acta Neuropathologica, 132(1), 59-75 (2016)

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