SAB4500820

Anti-THRB antibody produced in rabbit

affinity isolated antibody

• Synonym(s): Coagulation factor II, F2, THRB
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen 70 kDa
• species reactivity: human, mouse, rat
• concentration: ~1 mg/mL
• technique(s): ELISA: 1:10000; immunofluorescence: 1:100-1:500; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• NCBI accession no.: P00734
• UniProt accession no.: P00734
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... F2(2147)

Description

General description

Anti-THRB Antibody detects endogenous levels of total THRB protein.

Thyroid hormone receptor β; (THRβ) is encoded by the gene mapped to human chromosome 3p. THRβ exist in two isoforms, THRβ1 widely expressed in brain, liver and kidney and THRβ2 expressed specifically in hypothalamus and pituitary. The encoded protein contains a C- terminal ligand-binding and dimerization domain, a DNA-binding domain and a transactivation domain.

Immunogen

The antiserum was produced against synthesized peptide derived from human THRB.

Immunogen Range: 391-440

Biochem/physiol Actions

Thyroid hormone receptor β (THRβ) mediates the biological functions of thyroid hormones (TH). THRβ is down-regulated in several human malignancies including papillary thyroid carcinomas (PTCs). Loss of heterozygosity in THRβ and its proximal microsatellite markers might play a crucial role in tumorigenesis and development in invasive breast cancer. Deletion of the gene coding for THRβ leads to generalized thyroid hormone resistance (GTHR). THRβ plays a vital role in the regulation of specific mRNA and miRNA in T3-induced cardiac hypertrophy and alteration of heart functions in mice.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 12 - Non Combustible Liquids
• wgk_germany: nwg
• flash_point_f: Not applicable
• flash_point_c: Not applicable