AntiAGS5, AntiDCIP, AntiHD domain containing 1, AntiHDDC1, AntiMOP-5, AntiOTTHUMP00000030889, AntiSAM domain and HD domain 1, AntiSAM domain- and HD domain-containing protein 1, AntiSBBI88
SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 (SAMHD1) is a deoxynucleoside triphosphate triphosphohydrolase with sterile alpha motif (SAM) and a dGTP-regulated dNTP hydrolase domain (HD). SAMHD1 gene is mapped to human chromosome 20q11.23.
Immunogen
SAMHD1 purified recombinant protein
Biochem/physiol Actions
SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 (SAMHD1) is a key enzyme, which controls the levels of dinucleotide triphosphates. It also acts as an immune response factor cum restriction factor for many virues including the human immunodeficiency virus (HIV) hepatitis B virus (HBV) and herpes simplex virus 1 (HSV-1). SAMHD1 interferon-stimulated gene (ISG) also regulates the human cytomegalovirus and papillomavirus life cycles. Mutation in the SAMHD1 leads to imbalance in dinucleotide levels and is implicated in Aicardi‐Goutières syndrome (AGS) Mutation in SAMHD1 along with Three Prime Repair Exonuclease 1 (TREX1) and Stimulator of interferon genes (STING) genes is also correlated to familial chilblain lupus (FCL).
Physical form
Solution in Dulbecco′s Modified Eagle′s Medium with 10% fetal calf serum and 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
12 - Non Combustible Liquids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Certificates of Analysis (COA)
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SAMHD1 Regulates Human Papillomavirus 16-Induced Cell Proliferation and Viral Replication during Differentiation of Keratinocytes
James CD, et al.
mSphere, 4(4), e00448-e00419 (2019)
Autosomal dominant inheritance of a heterozygous mutation in SAMHD1 causing familial chilblain lupus
Ravenscroft JC, et al.
American Journal of Medical Genetics. Part A, 155(1), 235-237 (2011)
SAMHD1-deficient fibroblasts from Aicardi-Goutieres Syndrome patients can escape senescence and accumulate mutations
Franzolin E, et al.
Faseb Journal, 34(1), 631-647 (2020)
Microarray CGH analysis of hematological patients with del (20q)
Wu C, et al.
International Journal of Hematology, 102(5), 617-625 (2015)
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