SAB3500033

Anti-ZBED3 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution, ab2

• Synonym(s): Anti-Zinc finger BED-type domain containing 3
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: predicted mol wt 26 kDa
• species reactivity: human, rat, mouse
• technique(s): indirect ELISA: suitable; western blot: suitable
• NCBI accession no.: NP_115743
• UniProt accession no.: Q96IU2
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... ZBED3(84327)

Description

Immunogen

ZBED3 antibody was raised against a 17 amino acid peptide from near the amino terminus of human ZBED3.

Features and Benefits

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Target description

Axin is a key modulator of the Wnt/beta-catenin pathway and acts as a scaffold protein in phosphorylating and degrading cytoplasmic beta-catenin. ZBED3, a member of the Zinc finger BED-type domain containing superfamily, has been recently identified as an Axin-interacting protein and has been suggested to modulate the Wnt/beta-catenin signaling pathway. RNA interference (RNAi) experiments targeting ZBED3 RNA attenuated Wnt-induced beta-catenin accumulation, lymphoid enhancer binding factor-1-dependent luciferase reporter activity, and Wnt gene expression. Despite its predicted molecular weight, ZBED3 often migrates at a higher position in SDS-PAGE. This antibody is predicted to have no cross-reactivity to ZBED1 or ZBED2.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3500033.

Physical form

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable