Tumor associated calcium signal transducer 2 (TACSTD2), also known as trophoblast cell surface antigen 2 (TROP2), is a 36 kDa protein and part of the TACSTD family. The gene encoding this cell surface glycoprotein is localized on human chromosome 1p32.1.
Immunogen
Peptide with sequence C-HYEQPTIQIELRQN from the internal region of the protein sequence according to NP_002344.2.
Biochem/physiol Actions
Trophoblast cell surface antigen 2 (TROP2) has a role in epithelial-mesenchymal transition. It modulates stem cell activity and is crucial in promoting cell self-renewal and survival. TROP2 increases intracellular calcium levels. The protein is overexpressed in many cancers. It has been shown to influence the proliferation and migration of gallbladder cancer cells.
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Physical form
Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.
Increased expression of TROP2 in airway basal cells potentially contributes to airway remodeling in chronic obstructive pulmonary disease.
Liu Q, et al.
Respiratory Research, 17(1), 159-159 (2016)
TROP2 promotes proliferation, migration and metastasis of gallbladder cancer cells by regulating PI3K/AKT pathway and inducing EMT.
Li X, et al.
Oncotarget, 8(29), 47052-47052 (2017)
Overexpression of trophoblast cell surface antigen 2 as an independent marker for a poor prognosis and as a potential therapeutic target in epithelial ovarian carcinoma.
Xu N,et al.
International Journal of Experimental Pathology, 97(2), 150-158 (2016)
TROP2: a novel prognostic marker in squamous cell carcinoma of the oral cavity.
Fong D, et al.
Modern Pathology, 21(2), 186-186 (2008)
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