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SAB2501042

Sigma-Aldrich

Anti-TIP30/CC3 antibody produced in goat

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-HIV-1 Tat interactive protein 2, Anti-HTATIP2, Anti-Tat-interacting protein (30 kDa)

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

goat

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

indirect ELISA: suitable
western blot: suitable

UniProt accession no.

Q9BUP3

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... HTATIP2(10553)

Related Categories

General description

Tat-interacting protein 30 (TIP30), also called CC3/ HIV-1 tat interactive protein 2 (HTATIP2), is a putative tumor suppressor. It is encoded by the gene mapped to human chromosome 11p15.1. TIP30 is primarily localized in cytoplasm and it belongs to short-chain dehydrogenases/reductase (SDR) family. The encoded protein is extensively expressed in various human tissues, such as the heart, brain, lung, kidney and pancreas.

Immunogen

Peptide with sequence AETEALSKLREDFR-C from the N Terminus of the protein sequence according to NP_006401.

Biochem/physiol Actions

Tat-interacting protein 30 (TIP30) has an ability to promote apoptosis and suppress metastasis and angiogenesis. It is also implicated in regulation of DNA repair and tumor cell metabolism. Down-regulated expression of the gene is associated with the development of various cancers, including melanoma, breast cancer, neuroblastoma, glioblastoma, colon cancer, lung cancer and hepatocellular carcinoma. Elevated expression of the gene in glioma cells inhibits tumor proliferation, metastasis and migration. Thus, TIP30 can be considered as a potent target for treating glioma patients.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

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pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H315,H319

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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TIP30: a novel tumor-suppressor gene.
Yu X, et al.
Oncology Research, 22(5-6), 339-348 (2015)
Overexpression of TIP30 inhibits the growth and invasion of glioma cells
Hu Y, et al.
Molecular Medicine Reports, 13(1), 605-612 (2016)
TIP30 Deficiency Increases Susceptibility to Tumorigenesis
Ito M, et al.
Cancer Research, 63(24), 8763-8767 (2003)
Tat-Interacting Protein 30 (TIP30) Expression Serves as a New Biomarker for Tumor Prognosis: A Systematic Review and Meta-Analysis
Xu T, et al.
PLoS ONE, 11(12), e0168408-e0168408 (2016)
Xin Tong et al.
The American journal of pathology, 174(5), 1931-1939 (2009-04-08)
The HIV Tat-interacting protein (TIP30), also called CC3 or HTIP2, is encoded by Tip30, a putative tumor-suppressor gene located on human chromosome 11p15.1. In this study, we investigated the role of TIP30 in the progression and metastasis of lung cancer.

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