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S4451

Sigma-Aldrich

Sal003

≥98% (HPLC)

Synonym(s):

(2E)-3-Phenyl-N-[2,2,2-trichloro-1-[[[(4-chlorophenyl)amino]thioxomethyl]amino]ethyl]-2-propenamide, 3-Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide

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$145.35
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$612.00

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5 MG
$145.35
25 MG
$612.00

About This Item

Empirical Formula (Hill Notation):
C18H15Cl4N3OS
CAS Number:
1164470-53-4
Molecular Weight:
463.21
MDL number:
MFCD00361095
UNSPSC Code:
12352200
PubChem Substance ID:
329824543
NACRES:
NA.77

$145.35

List price$153.00Save 5%
Web-Only Promotion

Available to ship onApril 08, 2025Details

Request a Bulk Order

assay

≥98% (HPLC)

form

powder

storage condition

desiccated
protect from light

color

white to off-white

solubility

DMSO: ≥10 mg/mL

compatibility

for use with Bio-Rad CFX96

storage temp.

2-8°C

SMILES string

Clc1ccc(NC(=S)NC(NC(=O)\C=C\c2ccccc2)C(Cl)(Cl)Cl)cc1

InChI

1S/C18H15Cl4N3OS/c19-13-7-9-14(10-8-13)23-17(27)25-16(18(20,21)22)24-15(26)11-6-12-4-2-1-3-5-12/h1-11,16H,(H,24,26)(H2,23,25,27)/b11-6+

InChI key

TVNBASWNLOIQML-IZZDOVSWSA-N

Application

Sal003 was used to study the role of eIF2α in Subtilase cytotoxin-induced apoptosis in HeLa cells.[1]

Biochem/physiol Actions

Sal003 inhibits the late long-term potentiation (L-LTP) and long-term memory formation in mammalian hippocampal slices. The effect of Sal003 on L-LTP is mediated by the transcription factor, ATF4.[2][3]
Sal003 is a potent and cell-permeable eIF-2a phosphatase inhibitor.

pictograms

Environment
GHS09

signalword

Warning

hcodes

H410

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000337748
0000175579
119K4624V
119K4624

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Charles A Hoeffer et al.
Neuron, 54(2), 186-189 (2007-04-20)
A critical molecular requirement underlying many forms of long-lasting synaptic plasticity and memory is the de novo synthesis of mRNAs and proteins. In a recent paper in Cell, Costa-Mattioli et al. present data from a pharmacogenetic study that places a
Mauro Costa-Mattioli et al.
Neuron, 61(1), 10-26 (2009-01-17)
Long-lasting forms of synaptic plasticity and memory are dependent on new protein synthesis. Recent advances obtained from genetic, physiological, pharmacological, and biochemical studies provide strong evidence that translational control plays a key role in regulating long-term changes in neural circuits
Raquel Amorim et al.
PLoS neglected tropical diseases, 11(7), e0005775-e0005775 (2017-07-18)
Zika virus (ZIKV), a member of the Flaviviridae family, is the most recent emerging arbovirus with pandemic potential. During infection, viruses trigger the host cell stress response, leading to changes in RNA translation and the assembly of large aggregates of
Philippos Peidis et al.
Aging, 2(10), 669-677 (2010-11-16)
Histone deacetylase inhibitors (HDACi) comprise a family of chemotherapeutic agents used in the clinic to treat cutaneous T-cell lymphoma and tested for the therapy of other malignancies. Previous reports have shown that eIF2α phosphorylation is induced upon treatment with HDACi.
Marta Carrara et al.
Nature structural & molecular biology, 24(9), 708-716 (2017-08-02)
The reversible phosphorylation of proteins controls most cellular functions. Protein kinases have been popular drug targets, unlike phosphatases, which remain a drug discovery challenge. Guanabenz and Sephin1 are selective inhibitors of the phosphatase regulatory subunit PPP1R15A (R15A) that prolong the
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