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S1136

Sigma-Aldrich

[Nle11]-Substance P

≥97% (HPLC)

Synonym(s):

Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Nle-NH2

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About This Item

Empirical Formula (Hill Notation):
C64H100N18O13
CAS Number:
57462-42-7
Molecular Weight:
1329.59
MDL number:
MFCD00076785
UNSPSC Code:
12352200
PubChem Substance ID:
24899461

assay

≥97% (HPLC)

storage temp.

−20°C

SMILES string

CCCCC(NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(Cc1ccccc1)NC(=O)C(Cc2ccccc2)NC(=O)C(CCC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C3CCCN3C(=O)C(CCCCN)NC(=O)C4CCCN4C(=O)C(N)CCCNC(N)=N)C(N)=O

InChI

1S/C64H100N18O13/c1-4-5-22-42(54(69)86)75-58(90)46(34-38(2)3)74-53(85)37-73-55(87)47(35-39-17-8-6-9-18-39)79-59(91)48(36-40-19-10-7-11-20-40)80-57(89)43(26-28-51(67)83)76-56(88)44(27-29-52(68)84)77-60(92)50-25-16-33-82(50)63(95)45(23-12-13-30-65)78-61(93)49-24-15-32-81(49)62(94)41(66)21-14-31-72-64(70)71/h6-11,17-20,38,41-50H,4-5,12-16,21-37,65-66H2,1-3H3,(H2,67,83)(H2,68,84)(H2,69,86)(H,73,87)(H,74,85)(H,75,90)(H,76,88)(H,77,92)(H,78,93)(H,79,91)(H,80,89)(H4,70,71,72)

InChI key

ZEPTUBCWHRSMIP-UHFFFAOYSA-N

Biochem/physiol Actions

Substance P analog that avoids methionine oxidation problems

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

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E Escher et al.
Journal of medicinal chemistry, 25(4), 470-475 (1982-04-01)
Substance P (Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-MetNH2, SP) is an undecapeptide with important properties as a neurotransmitter and with other functions. No specific antagonists and no long-acting analogues of this peptide hormone are known to date. In order to reach these goals, analogues of
R Landgraf et al.
Die Pharmazie, 38(2), 108-110 (1983-02-01)
The studies concerning the problem of whether an exogenous neuropeptide is able to enter the brain tissue were extended to the undecapeptide Substance P (SP). The amount of radioactivity 15 s after intracarotid injection of [3H] Nle11-SP or [14C] inulin
T N Akopyan et al.
Acta biologica et medica Germanica, 40(6), 779-784 (1981-01-01)
An ion exchange batchwise procedure was developed for the estimation of substance P degradation by rat brain fractions using 3H[Nle11]substance P as tracer. With this very sensitive and rapid method an especially high degradative activity was found among others in
R E Chipkin et al.
Archives internationales de pharmacodynamie et de therapie, 240(2), 193-202 (1979-08-01)
Substance P (SP) and several analogs and fragments have been synthesized and evaluated on non-stimulated and stimulated guinea-pig ileum. In the former test system the potency order was as follows: SP(4--11) greater than SP = [Tyr7]-SP = [Eth11]-SP = [Nle11]-SP

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