PZ0337

UK-432097

≥98% (HPLC)

• Synonym(s): 6-(2,2-Diphenylethylamino)-9-((2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxytetrahydrofuran-2-yl)-N-(2-(3-(1-(pyridin-2-yl)piperidin-4-yl)ureido)ethyl)-9H-purine2-carboxamide
• Empirical Formula (Hill Notation): C₄₀H₄₇N₁₁O₆
• CAS Number: 380221-63-6
• Molecular Weight: 777.87
• MDL number: MFCD28137759
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• shipped in: wet ice
• storage temp.: −20°C
• SMILES string: O[C@@H]1[C@@H](C(NCC)=O)O[C@@H](N2C=NC(C2=N3)=C(NCC(C4=CC=CC=C4)C5=CC=CC=C5)N=C3C(NCCNC(NC(CC6)CCN6C7=CC=CC=N7)=O)=O)[C@@H]1O
• InChI: 1S/C40H47N11O6/c1-2-41-37(54)33-31(52)32(53)39(57-33)51-24-46-30-34(45-23-28(25-11-5-3-6-12-25)26-13-7-4-8-14-26)48-35(49-36(30)51)38(55)43-19-20-44-40(56)47-27-16-21-50(22-17-27)29-15-9-10-18-42-29/h3-15,18,24,27-28,31-33,39,52-53H,2,16-17,19-23H2,1H3,(H,41,54)(H,43,55)(H2,44,47,56)(H,45,48,49)/t31-,32+,33-,39+/m0/s1
• InChI key: ZOTHAEBAWXWVID-HXEFRTELSA-N

Description

Biochem/physiol Actions

Highly selective A2A Adenosine receptor full agonist

UK-432097 is a selective adenosine receptor A_2AAR full agonist with EC50 of 0.66 ± 0.19 nM. It was recently used to map the structure of the active state of the adenosine A2A receptor.

Legal Information

Sold for research purposes under agreement from Pfizer Inc.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable