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PZ0248

Sigma-Aldrich

PF-06447475

≥98% (HPLC)

Synonym(s):

3-[4-(4-Morpholinyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-benzonitrile

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About This Item

Empirical Formula (Hill Notation):
C17H15N5O
CAS Number:
1527473-33-1
Molecular Weight:
305.33
UNSPSC Code:
12352200
PubChem Substance ID:
329823790
NACRES:
NA.77

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 10 mg/mL, clear

storage temp.

room temp

SMILES string

N#CC1=CC=CC(C2=CNC3=NC=NC(N4CCOCC4)=C32)=C1

InChI

1S/C17H15N5O/c18-9-12-2-1-3-13(8-12)14-10-19-16-15(14)17(21-11-20-16)22-4-6-23-7-5-22/h1-3,8,10-11H,4-7H2,(H,19,20,21)

InChI key

BHTWDJBVZQBRKP-UHFFFAOYSA-N

Biochem/physiol Actions

PF-06447475 is a potent and selective LRRK2 inhibitor.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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Antonella Marte et al.
Journal of neurochemistry, 150(3), 264-281 (2019-05-31)
Leucine-rich repeat kinase 2 (LRRK2) is a large multidomain scaffolding protein with kinase and GTPase activities involved in synaptic vesicle (SV) dynamics. While its role in Parkinson's disease has been largely investigated, little is known about LRRK2 physiological role and

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