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Key Documents

PZ0187

Sigma-Aldrich

Begacestat

≥98% (HPLC)

Synonym(s):

5-Chloro-N-[(1S)-3,3,3-trifluoro-1-(hydroxymethyl)-2- (trifluoromethyl)propyl] thiophene-2-sulfonamide, GSI-953

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5 MG
$116.00
25 MG
$451.00

$116.00


Estimated to ship onMarch 26, 2025



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5 MG
$116.00
25 MG
$451.00

About This Item

Empirical Formula (Hill Notation):
C9H8ClF6NO3S2
CAS Number:
Molecular Weight:
391.74
MDL number:
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.77

$116.00


Estimated to ship onMarch 26, 2025


Quality Level

assay

≥98% (HPLC)

form

powder

color

white to tan

solubility

DMSO: ≥15 mg/mL

storage temp.

2-8°C

SMILES string

OC[C@@H](NS(=O)(=O)c1ccc(Cl)s1)C(C(F)(F)F)C(F)(F)F

InChI

1S/C9H8ClF6NO3S2/c10-5-1-2-6(21-5)22(19,20)17-4(3-18)7(8(11,12)13)9(14,15)16/h1-2,4,7,17-18H,3H2/t4-/m1/s1

InChI key

PSXOKXJMVRSARX-SCSAIBSYSA-N

Biochem/physiol Actions

Begacestat (GSI-953) is a selective γ-secretase inhibitor that selectively inhibits cleavage of APP over Notch.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Dingding Mo et al.
Cells, 9(10) (2020-10-03)
Alzheimer's disease (AD) is an age-related detrimental dementia. Amyloid beta peptides (Aβ) play a crucial role in the pathology of AD. In familial AD, Aβ are generated from the full-length amyloid beta precursor protein (APP) via dysregulated proteolytic processing; however

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