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Key Documents

PZ0124

Sigma-Aldrich

CP-66713

≥98% (HPLC)

Synonym(s):

8-chloro-1-phenyl-[1,2,4]triazolo[4,3-a]quinoxalin-4-amine, PF-1716311

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About This Item

Empirical Formula (Hill Notation):
C15H10ClN5
CAS Number:
Molecular Weight:
295.73
MDL number:
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.77

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Quality Level

assay

≥98% (HPLC)

form

powder

color

white to off-white

solubility

DMSO: ≥5 mg/mL

storage temp.

2-8°C

SMILES string

Nc1nc2ccc(Cl)cc2n3c(nnc13)-c4ccccc4

InChI

1S/C15H10ClN5/c16-10-6-7-11-12(8-10)21-14(9-4-2-1-3-5-9)19-20-15(21)13(17)18-11/h1-8H,(H2,17,18)

InChI key

PBENJWAFQLORQL-UHFFFAOYSA-N

Biochem/physiol Actions

CP-66713 is an adenosine A2 receptor antagonist.

Features and Benefits

This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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T Matsugi et al.
Investigative ophthalmology & visual science, 38(13), 2695-2701 (1998-01-07)
To investigate the effect of adenosine on the contractile tone of cultured bovine retinal pericytes. Changes in the contractile tone were quantified as the changes in the summed length of wrinkles induced by pericytes on the silicone surface on which
S Fujii et al.
Neuroscience letters, 148(1-2), 148-150 (1992-12-14)
The effects of the adenosine A2 receptor antagonist CP-66713 on the reversal of long-term potentiation (LTP) were studied in CA1 neurons of guinea pig hippocampal slices. Reduction of LTP (depotentiation, DP) was effected by delivering a train of low-frequency afferent
E M O'Kane et al.
European journal of pharmacology, 362(1), 17-25 (1998-12-29)
Previous work has been carried out on the effects of adenosine on transmitter release and on the excitability of postsynaptic neurones, but little is known about the effects of adenosine on the coupling between the two. In this study, we
Y Zhang et al.
European journal of pharmacology, 313(3), 237-242 (1996-10-17)
Propentofylline is an atypical xanthine derivative that blocks adenosine uptake and has been shown to protect against ischemia-induced cerebral damage. We have studied the effect of propentofylline on recruitment of polymorphonuclear leukocytes during acute peritonitis induced by zymosan in mice.
B B Fredholm et al.
European journal of pharmacology, 380(2-3), 197-202 (1999-10-08)
We have examined the potency of several adenosine receptor antagonists at adenosine A1 and A2A receptors using quantitative autoradiography and have compared the results with those of previous studies using the same radioligands in membrane preparations. The agonists [3H]cyclohexyladenosine and

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