PLA0119

Rabbit anti-NONO Antibody, Affinity Purified

Powered by Bethyl Laboratories, Inc.

• Synonym(s): 52 kDa subunit, 54 kDa nuclear RNA- and DNA-binding protein, 54-kD, 55 kDa nuclear protein, DNA-binding p52/p100 complex, MRXS34, NMT55, NRB54, NonO protein, Nuclear RNA-binding protein, P54, P54NRB, PPP1R114, non-Pou domain-containing octamer (ATGCAAAT) binding protein, p54(nrb), protein phosphatase 1, regulatory subunit 114
• UNSPSC Code: 12352203
• NACRES: NA.41
• species reactivity: rat, mouse, human
• application: IHC; IP; WB
• technique(s): immunohistochemistry: 1:200-1:1,000; immunoprecipitation (IP): 1- 4 μg/mg; western blot: 1:2,000- 1:10,000
• citations: 1

Properties

• biological source: rabbit
• Quality Level: 100
• antibody form: affinity purified immunoglobulin
• antibody product type: primary antibodies
• grade: Powered by Bethyl Laboratories, Inc.
• species reactivity: rat, mouse, human
• technique(s): immunohistochemistry: 1:200-1:1,000; immunoprecipitation (IP): 1- 4 μg/mg; western blot: 1:2,000- 1:10,000
• accession no.: NP_031389.3
• UniProt accession no.: Q15233
• shipped in: wet ice
• storage temp.: 2-8°C
• target post-translational modification: unmodified
• Gene Information: rabbit ... NONO(4841)

Description

Immunogen

The epitope recognized by PLA0119 maps to a region between residues 350 and 400 of human Non-POU Domain Containing, Octamer-binding using the numbering given in entry NP_031389.3 (GeneID 4841).

Physical form

Tris-buffered Saline containing 0.1% BSA containing 0.09% Sodium Azide

Other Notes

Non-POU-domain-containing octamer binding protein (NONO) is a member of the DBHS (drosophila behavior, human splicing) domain-containing family and is an RNA- and DNA- binding protein. NONO and other DBHS domain-containing proteins are multifunctional and are reported to be involved in transcriptional regulation, mRNA processing, and DNA non-homologous end joining (NHEJ). NONO functions as a coregulator of the androgen receptor (AR) and also regulates cAMP transcriptional activity by interacting with gene promoter elements. NONO is also involved in pre-mRNA splicing through an interaction with U5 snRNA and can stimulate DNA nonhomologous end joining (NHEJ) through the interaction with ku70/G22p and ku80/XRCC5 dimers.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 12 - Non Combustible Liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable